Accès ouvert
2026
article
OpenAlex
Ben Li, Mariam Zakaria, Mo’ath Bani Ali, Ola Kassem et autres
Background/Objectives: Peripheral artery disease (PAD) remains underdiagnosed and suboptimally treated, with limited disease awareness and underutilization of available diagnostic strategies representing important contributing factors. The ankle–brachial index (ABI) is the gold-standard screening test for PAD and has been shown to correlate with …
ca, ae
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Accès ouvert
2026
article
OpenAlex
Ben Li, Farah Shaikh, Abdelrahman Zamzam, Muzammil H. Syed et autres
Serum biomarkers associated with abdominal aortic aneurysm (AAA) have been studied individually; however, an algorithm that considers panel of proteins to inform AAA prognosis may improve predictive accuracy. We conducted a prognostic study using a prospectively recruited cohort of patients with and …
ca, gb, ae
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ben Li, Hamzah Khan, Farah Shaikh, Abdelrahman Zamzam et autres
Background: While trefoil factor 3 (TFF3) has been linked to cardiovascular disease, its role in peripheral artery disease (PAD) remains largely unexplored. In this prospective study, we assessed three pre-selected circulating biomarkers and found that TFF3 demonstrated the strongest association with the …
ca, gb, ae
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Accès ouvert
2026
article
OpenAlex
Ben Li, Adam M Khalil, Abdallah Bakeer, Abdelrahman Zamzam et autres
Background and Objectives: Peripheral artery disease (PAD) is a common manifestation of systemic atherosclerosis associated with significant morbidity and mortality, yet it remains underdiagnosed due to limited routine screening and its often-asymptomatic presentation. Although the ankle–brachial index (ABI) is the gold standard …
ca, ae
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ben Li, Mariam Zakaria, Abdelrahman Zamzam, Shaima Alqrain et autres
Background/Objectives: The ankle–brachial index (ABI) is the gold-standard test for peripheral artery disease (PAD). However, ABI is conventionally calculated using the higher of the dorsalis pedis (DP)- or posterior tibial (PT)-derived ankle pressure values, which may mask clinically relevant differences between arterial …
ca, ae
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ben Li, Shaima Alqrain, Farah Shaikh, László Göbölös et autres
Background: Peripheral artery disease (PAD) impacts more than 200 million individuals globally. Despite its prevalence, management remains suboptimal, partly due to the lack of reliable blood-based biomarkers. The ankle–brachial index (ABI), the current gold-standard test for PAD, is limited by inter-operator variability, …
ca, ae
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Muzammil H. Syed, Abdelrahman Zamzam, Farah Shaikh, Ori D. Rotstein et autres
Background/Objective: Peripheral arterial disease (PAD) is a widespread but underdiagnosed manifestation of systemic atherosclerosis, associated with high morbidity and mortality. Traditional diagnostic methods such as the ankle-brachial index (ABI) have limited sensitivity in certain populations, highlighting the need for reliable blood-based biomarkers. …
ca, ae
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Accès ouvert
2026
article
OpenAlex
Mohammed E Khalil, Adam M Khalil, Mo’ath Bani Ali, Rami Bani Ata et autres
BACKGROUND: Heart failure is a global health burden, yet artificial intelligence (AI) screening tools for left ventricular ejection fraction (LVEF) have largely been validated in Western populations with limited data from the Middle East. We aimed to develop and validate an interpretable-first, …
us, ae, ca
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Accès ouvert
2026
article
OpenAlex
Noa Agid, Peter Andrisani, Hamzah Khan, Mohammad Qadura et autres
Purpose: This study aimed to investigate the relationship between the two biomarkers, von Willebrand factor (VWF) and ADAMTS13, and major adverse limb events (MALE) in patients with peripheral artery disease (PAD). Materials and Methods: After obtaining informed consent, baseline blood samples were …
ca
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Accès ouvert
2026
article
OpenAlex
Hien Chi Nguyen, A. Robert Singh, Christina A. Castellani, Mohammad Qadura et autres
Background: Fatty acid-binding protein 3 (FABP3) is released in circulation following myocardial infarction, and an increased level of circulatory FABP3 has also been reported in peripheral artery disease patients, exposing endothelial cells to higher levels of FABP3. Recently, loss of endothelial FABP3 …
ca
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Accès ouvert
2025
article
OpenAlex
Hamzah Khan, Sayyid Frljuckic, Abdelrahman Zamzam, Retaj Ashour et autres
Peripheral arterial disease (PAD) is an atherosclerotic disease caused by the narrowing of peripheral arteries due to atheromatous plaque build-up. Angiogenesis can be beneficial in patients with PAD however it may contribute to negative long-term cardiovascular outcomes. Vascular endothelial growth factor-A (VEGF/VEGF-A) …
ca, ie, gb, us
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2025
conference-abstract
OpenAlex
Mohammad Qadura, Houssam K. Younes, Jason A. Chin, Abdelrahman Zamzam et autres
Background: Aspirin therapy is well-established for secondary prevention of cardiovascular events; however, its role in modifying amputation outcomes in patients with peripheral artery disease (PAD) remains unclear. Research Question: Does aspirin therapy influence the likelihood of major versus minor amputations in PAD? …
ae
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