Bryan J. Matthews

Profiling and Targeting of Regulatory RNAs to Upregulate Gene Expression

Brynn N. Akerberg, Bryan J. Matthews, Yuting Liu, Cécile Mathieu et autres

Abstract Transcription of long noncoding RNAs (lncRNAs), including enhancer RNAs (eRNAs) and promoter-associated RNAs (paRNAs), collectively termed regulatory RNAs (regRNAs), is a hallmark of active gene expression, yet it remains unknown whether regRNAs can be targeted to selectively enhance transcription in cis …

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Author Correction: Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews et autres

“G.R. performed computational analyses and wrote the manuscript draft. Y.Y., B.A., B.M., J.W., and A.A.A. performed experiments. G.G., J.H., and Y.L. performed computational analyses. D.H., L.C.B., S.J.E., I.G., A.S., A.A.S., R.T.F., Y.L., and D.B. supervised the experiments and computational analyses. All authors …

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Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews et autres

Microglia are the resident immune cells in the brain that play a key role in driving neuroinflammation, a hallmark of neurodegenerative disorders. Inducible microglia-like cells have been developed as an in vitro platform for molecular and therapeutic hypothesis generation and testing. However, …

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Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews et autres

Abstract Background Microglia are the resident immune cells in the brain that play a key role in driving neuroinflammation, a hallmark of neurodegenerative disorders. Inducible microglia-like cells have been developed as an in vitro platform for molecular and therapeutic hypothesis generation and …

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Progranulin upregulation by antisense oligonucleotides targeting regRNAs for treatment of FTD‐GRN

Yeliz Yuva Aydemir, Ali Al Abdullatif, Gokul Ramaswami, Gabriel Golczer et autres

Abstract Background Heterozygous mutations in progranulin (GRN) gene leading to progranulin protein (PGRN) haploinsufficieny are the major genetic cause of GRN‐related frontotemporal dementia (FTD‐GRN)1, 2 and 3. Decreased levels of PGRN disrupt lysosome homeostasis, cause aberrant microglia activation and neuronal cell death …

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Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model

Bryan J. Matthews, Tisha Melia, David J. Waxman

Sex differences in gene expression are widespread in the liver, where many autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease. Here, we compare hepatic transcriptomic and epigenetic profiles of …

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Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model

Bryan J. Matthews, David J. Waxman

Abstract Sex differences in gene expression are widespread in the liver, where a large number of autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease. Here, we compare hepatic transcriptomic …

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Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Bryan J. Matthews, David J. Waxman

Several thousand sex-differential distal enhancers have been identified in mouse liver; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization and chromatin interactions are unknown. To address these issues, we first characterized 1847 mouse liver genomic …

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Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Bryan J. Matthews, David J. Waxman

Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Bryan J. Matthews, David J. Waxman

Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Bryan J. Matthews, David J. Waxman

Abstract Background: Sex differences in the transcriptome and epigenome are widespread in mouse liver and are associated with sex-bias in liver disease. Several thousand sex-differential distal enhancers have been identified; however, their links to sex-biased genes and the impact of any sex-differences …

Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Bryan J. Matthews, David J. Waxman

Abstract Background Sex differences in the transcriptome and epigenome are widespread in mouse liver and are associated with sex-bias in liver disease. Several thousand sex-differential distal enhancers have been identified; however, their links to sex-biased genes and the impact of any sex-differences …

us (code pays fourni par la source)