Isabel Potani

Pancreatic enzymes and bile acids alone and in combination for acutely ill, severely malnourished children: a multi-country double-blind randomised placebo-controlled trial

Robert Bandsma, Mohammod Jobayer Chisti, Wieger Voskuijl, Moses M. Ngari et autres

Background: Translocation of bacteria across the intestinal barrier has been postulated to contribute to mortality among severely malnourished children. Pancreatic enzymes (PE) and bile acids (BA) have anti-bacterial properties in the small intestine, but severe malnutrition is associated with impaired exocrine pancreatic …

ca, Kenya, bd, nl, Ouganda, Malawi, Afrique du Sud, us, gb, cn (code pays fourni par la source)

National and Sub-National Delivery of Balanced Energy and Protein (BEP) Supplements to Pregnant and Lactating Women in LMICs: Lessons from Multi-Country Implementation Case Studies

Mihaela C Kissell, Kaosar Afsana, Sufia Askari, Rimu Byadya et autres

The World Health Organization recommends the use of balanced energy protein (BEP) supplements during pregnancy in settings with a ≥ 20% prevalence of underweight women of reproductive age to reduce the risk of adverse health outcomes. Several countries are implementing BEP supplementation …

us, bd, ch, in, it, pk, np, Mozambique, th, nl (code pays fourni par la source)

Pancreatic Enzymes and/or Bile Acids for Acutely Ill Severely Malnourished Children – a Double-Blind Randomized Placebo-Controlled Trial

Robert Bandsma, Mohammod Jobayer Chisti, Wieger Voskuijl, Moses Mukaba Ngari et autres

ca, Kenya, bd, nl, Ouganda, kh, Malawi, us (code pays fourni par la source)

Pancreatic enzymes and/or bile acids for acutely ill severely malnourished children – a double-blind randomized placebo-controlled trial

Robert Bandsma, Mohammod Jobayer Chisti, Wieger Voskuijl, Moses Mukaba Ngari et autres

Abstract Background Translocation of bacteria across the intestinal barrier has been postulated to contribute to mortality among severely malnourished children. Pancreatic enzymes (PE) and bile acids (BA) have anti-bacterial properties in the small intestine, but severe malnutrition is associated with impaired exocrine …

ca, Kenya, bd, nl, Ouganda, Malawi, Afrique du Sud, us, gb, cn (code pays fourni par la source)

Applying WHO Prioritization Criteria for Moderate Wasting: Programmatic Implications

Isabel Potani, Zachary Tausanovitch, Grace Heymsfield, Christian Ritz et autres

The World Health Organization's 2023 recommendations for managing moderate wasting provide criteria for prioritizing children to receive specially formulated foods (SFF) rather than counseling alone. However, the practical programmatic impact of such prioritization is unclear. This secondary analysis aimed to describe the …

Malawi, us, dk, fr, Sénégal, fi, Mali, Kenya, gb (code pays fourni par la source)

The contribution of minimally invasive tissue sampling compared to antemortem-derived cause of death determination among inpatient child deaths: the minimally invasive tissue sampling in Malawi study

Wieger Voskuijl, Dennis Chasweka, Sarah Lawrence, Daniëlla Brals et autres

Background: Improved causes of death (CoD) understanding in low- and middle-income countries is needed to reduce child mortality. Compared to full autopsy, minimally invasive tissue sampling (MITS), using transcutaneous needle sampling, is a feasible, socially acceptable, and validated method. We aimed to …

Malawi, nl, Kenya, us, ca, gb, es (code pays fourni par la source)

Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort

Lei Xia, Hang Wu, Ali Faisal Saleem, Ezekiel Mupere et autres

BACKGROUND: Chronic exposure to aflatoxins is associated with liver cancer, impaired child growth, and compromised immune function. The Childhood Acute Illness and Nutrition (CHAIN) Network cohort was established to identify risk factors for mortality in acutely ill children admitted to nine hospitals …

gb, pk, Ouganda, us, Burkina Faso, Malawi, ca, nl, bd, Kenya, kh, cn (code pays fourni par la source)

Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

George Patton, Karly Cini, Yohannes Abate, Nasir Abbas et autres

BACKGROUND: Despite the well documented consequences of obesity during childhood and adolescence and future risks of excess body mass on non-communicable diseases in adulthood, coordinated global action on excess body mass in early life is still insufficient. Inconsistent measurement and reporting are …

Ten-year trends in clinical characteristics and outcome of children hospitalized with severe wasting or nutritional edema in Malawi (2011–2021): Declining admissions but worsened clinical profiles

Mphatso Chisala, Céline Bourdon, Emmanuel Chimwezi, Allison I Daniel et autres

BACKGROUND: Severe acute malnutrition (SAM) constitutes a substantial burden in African hospitals. Despite adhering to international guidelines, high inpatient mortality rates persist and the underlying contributing factors remain poorly understood. OBJECTIVE: We evaluated the 10-year trend (2011-2021) in clinical factors and outcomes …

gb, ca, Kenya, nl, Malawi (code pays fourni par la source)

Impact of HIV exposure without infection on hospital course and mortality among young children in sub-Saharan Africa: a multi-site cohort study

Christopher Lwanga, Peace Aber, Kirkby D. Tickell, Moses M. Ngari et autres

BACKGROUND: Although mortality risk associated with HIV is well described, HIV-exposed uninfected (HEU) young children are also at increased risk of hospitalization and death as compared to HIV-unexposed uninfected (HUU) children. The drivers of poor outcomes among HEU children remain unknown, limiting …

Ouganda, Kenya, us, ca, bd, gb (code pays fourni par la source)

The relationship between energy provided and growth during severe wasting treatment

Isabel Potani, Zachary Tausanovitch, Christian Ritz, André Briend et autres

Treatment of severe acute malnutrition aims at producing quick catch-up growth in children to decrease their short-term mortality risk. The extent to which catch-up growth is influenced by the amount of energy provided is unclear. This study assessed whether energy provided at …

Malawi, us, dk, fi, Éthiopie, Mali, be (code pays fourni par la source)

Trends in severe acute malnutrition admissions, characteristics, and treatment outcomes in Malawi from 2011 through 2019

Allison I Daniel, Sylvester Kathumba, Collins Mitambo, Dennis Chasweka et autres

Background: Community-based Management of Acute Malnutrition (CMAM) has been successfully implemented across Malawi, yet trends in admissions, characteristics, and treatment outcomes in children with severe acute malnutrition (SAM) have not been examined. The objective was therefore to investigate trends in admissions, characteristics …

ca, Malawi, nl (code pays fourni par la source)