Jian Q. Feng

Abstract 2961: Developing ADC-resistant tumor models for efficacy evaluation of next-generation anticancer therapies.

Jian Q. Feng, Fuyin Zhao, Xinlong Dong, A. Hua et autres

Abstract Introduction: Antibody-drug conjugates (ADCs) pair monoclonal antibodies with cytotoxic payloads. Trastuzumab deruxtecan (DS8201) targets HER2, and datopotamab deruxtecan (DS1062) targets TROP2. Both use a topoisomerase I inhibitor (Dxd) via a cleavable linker. After target-mediated internalization, proteases release the payload, causing DNA …

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NIR-II fluorescence projection technology for augmented-reality surgical navigation

Yuhuang Zhang, X Liu, Z. Liu, Changli Liu et autres

ABSTRACT NIR-II fluorescence imaging provides superior tissue penetration and clarity, yet its clinical use in surgical navigation is hindered by a critical workflow issue. Surgeons must divert their attention between the operative field and external monitors, increasing cognitive load and disrupting procedures. …

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World's first case of septic shock caused by a ruptured infected cyst of the lesser omentum

Wan Wu, Hongyin Liang, Xiao Wang, Jian Q. Feng

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Cage-Assembled Antigenic Particle Vaccine (CAP-V) Orchestrates Balanced Th1/Th2 Immunity and Potent Protection Against Alveolar Echinococcosis

Yang Zang, Jian Q. Feng, Yutong Peng, Wei Cui et autres

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Abstract B058: Antitumor activity and bystander killing effect of HER2 antibody-drug conjugates (ADCs) against tumors with different HER2 expression levels

A. Hua, Jian Q. Feng, Cui Nie, Jun Zhou et autres

Abstract Introduction Antibody-drug conjugates (ADCs) are a groundbreaking therapeutic strategy, and human epidermal growth factor receptor 2 (HER2) is a prominent target antigen for ADCs. Trastuzumab emtansine (T-DM1) was the 1st FDA approved HER2 ADC for patients with metastatic HER2-positive breast cancer. …

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MiR ‐20b‐Overexpressed BMSC ‐Derived Exosomes Target SIRT1 / BMP2 to Regulate Mitochondrial Autophagy and Osteogenesis in Osteoporosis

Fang Han, Ying Zheng, Jianwei Shen, Qiang Chen et autres

Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts and promote osteogenesis (OP), and the miRNAs carried by BMSCs-derived exosomes (BMSC-Exo) regulate osteoblast differentiation in bone-related diseases. Additionally, abnormal mitochondrial autophagy in osteoblasts mediated by the SIRT1/PINK1/Parkin signaling axis affects differentiation …

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Stimuli-responsive nanoparticles with tailorable elastin-like polypeptide chains for improved brain tumor targeting and therapy

Jinxia Huang, Yan Xia, Liping Wang, Jian Q. Feng et autres

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Chimeric collagen-like proteins with tunable structural heterogeneity for precise control and targeted doxorubicin delivery

Yan Xia, Yimiao Li, Jinxia Huang, Liping Wang et autres

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Rationally Engineered Coronavirus-mimicking Protein Nanocage Platform for Glioblastoma Targeted Delivery and Immunity Regulation

Jiaqi Li, Jian Q. Feng, Yue Ren, Liping Wang et autres

Abstract Glioblastoma (GBM) is one of the most aggressive and treatment-resistant brain tumors, owing to the dual challenges of the blood-brain barrier (BBB) and a profoundly immunosuppressive tumor microenvironment. However, few existing strategies are capable of simultaneously overcoming these two barriers, underscoring …

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Abstract 5524: Developing KRASG12C inhibitor-resistant tumor models for efficacy evaluation of next-generation anticancer therapies

Jian Q. Feng, Dan Zhang, A. Hua, Cui Nie et autres

Abstract Background: For decades, KRAS was considered undruggable due to the lack of suitable binding sites. However, advancements in bioengineering and chemistry have enabled the approval of targeted therapies. Success was first seen with allele-specific targeting of KRASG12C in non-small cell lung …

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Abstract 7270: Novel humanized cell and murine models expressing tumor-associated antigens for ADC toxicity and IO combination evaluation

Xiaoze Wang, Rong Wang, Kaixia Lian, Rongfei Lu et autres

Abstract Introduction: Antibody-drug conjugates (ADCs) represent a breakthrough therapeutic class that provides tumor-targeted cytotoxicity while stimulating immune responses, offering promising potential when combined with immunotherapies and particularly with PD-1 inhibitors. Traditional xenograft tumor models developed in immunodeficient mice are employed to evaluate …

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Chimeric Collagen-like Proteins with Tunable Structural Heterogeneity for Precise Control and Targeted Doxorubicin Delivery

Yan Xia, Yimiao Li, Jinxia Huang, Jian Q. Feng et autres

Abstract Protein-based drug delivery systems offer advantages such as genetic tunability, structural homogeneity, and high biocompatibility. However, precisely controlling the assembly of protein nanoparticles and establishing correlations between their macroscopic properties and molecular architecture remain significant challenges. Here, inspired by chimeric collagen-like …

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