Han Xiao

Cerebral Glucose Hypometabolism in Alzheimer’s Disease: A Meta-Analysis and Transcriptomic-Neuroimaging Study

Chuxin Huang, Yi Pan, Han Xiao, Yi-Xiang Wang et autres

Introduction: Cerebral glucose hypometabolism is known to occur in Alzheimer’s Disease (AD). However, the spatial pattern of these metabolic alterations remains inconsistent across studies, and the molecular mechanisms linking regional metabolic vulnerability to gene expression profiles are poorly understood, thus highlighting the …

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PTGIS inhibited osteogenic and promoted angiogenic differentiation of bone marrow mesenchymal stem cells via endoplasmic reticulum stress mediated PI3K/AKT signaling

Han Bao, Yi-Xiang Wang, Haoqing Yang, Huina Liu et autres

BACKGROUND: Mesenchymal stem cells (MSCs) play a key role in ectopic mineralization. Effective treatment requires both inhibiting pathological calcification and promoting vessel growth. While prostacyclin synthase (PTGIS) is critical for vascular health, its role in regulating osteogenic and angiogenic differentiation in MSCs …

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Impact of a National Volume-Based Procurement Policy in China on purchase of nucleoside/nucleotide analog drugs for the treatment of chronic hepatitis B virus infection

Ziheng Yang, Han Xiao, Yue Zhao, Tiantian Yao et autres

BACKGROUND: Hepatitis B virus (HBV) infection is a global public health issue, with approximately 1.5 million new infections and around 820,000 deaths annually around the globe. China carries the heaviest burden of HBV infection in the world, making it crucial to improve …

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Impact of national volume-based procurement policy on drugs treating chronic Myelogenous Leukemia

Zhao Yang, Yiran Li, Siyu Liu, Han Xiao et autres

BACKGROUND: Tyrosine kinase inhibitors (TKIs) have been shown to improve survival rate in chronic myeloid leukemia (CML) patients, but their high costs impose a significant economic burden. This study aimed to evaluate the impact of China's National Volume-Based Procurement (NVBP) policy on …

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Study on the Effects of National Volume‐Based Procurement of Chemical Drugs on Chinese Patent Medicines: Lipid‐Lowering Drugs as an Example

Zhao Yang, Han Xiao, Xiaoting Zhao, Qiyun Zhu et autres

Background: Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. This study aims to explore the impact of national volume-based procurement (NVBP) on Chinese patent medicines and provide evidence for improving policies and promoting rational drug use. Methods: The study was …

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Identification of key genes underlying radiosensitivity and radioresistance in endometrial cancer through integrated bioinformatics analysis

Chunhui Wan, Lei Zhang, Ting Yu, Hui Lü et autres

Introduction: Radiation therapy is crucial in the treatment of endometrial cancer (UCEC). Patients exhibit significant variability in radiosensitivity, affecting therapeutic effect. Scarcity of studies exploring the gene-radiosensitivity relationship based on clinical data. Underlying molecular mechanisms of radiosensitivity and radioresistance require further investigation. …

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Anti-α-1,4-D-polygalacturonic acid antibodies as a new biomarker for juvenile idiopathic arthritis

Jiqian Huang, Zhijing Wu, Wei Quan, Xiaohua Ye et autres

OBJECTIVE: Diagnosing juvenile idiopathic arthritis (JIA) is challenging. Our study aimed to investigate the clinical significance of anti-α-1,4-D-polygalacturonic acid (PGA) antibodies in JIA, focusing on their role in diagnosis and assessing disease activity. METHODS: In this prospective case-control study, we examined variations …

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Study on the Effects of the National Volume-Based Procurement of Chemical Drugs on Chinese Patent Medicines: Lipid-Lowering Drugs as an Example

Zhao Yang, Han Xiao, Liang Pei, Xiaoting Zhao et autres

Abstract Background China implemented National Volume-Based Procurement (NVBP) to reduce drug prices while also changing the structure of medication in medical institutions. However, the effects of NVBP on Chinese patent medicines are unknown. Methods In this study, we examine the effect of …

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[Ginsenoside Re regulates mitochondrial biogenesis through Nrf2/HO-1/PGC-1α pathway to reduce hypoxia/reoxygenation injury in H9c2 cells].

Gaojie Xin, Yuanyuan Chen, Zixin Liu, Shujuan Xu et autres

This article explored the mechanism by which ginsenoside Re reduces hypoxia/reoxygenation(H/R) injury in H9c2 cells by regulating mitochondrial biogenesis through nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)/peroxisome prolife-rator-activated receptor gamma coactivator-1α(PGC-1α) pathway. In this study, H9c2 cells were cultured in hypoxia for 4 …

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Ultrasound-guided fluid resuscitation versus usual care guided fluid resuscitation in patients with septic shock: a systematic review and meta-analysis

Zheyuan Chen, Han Xiao, Ying Liu, Mengjun Wang et autres

Abstract Background Ultrasound is widely used in critical care for fluid resuscitation in critically ill patients. We conducted a systematic review to assess the relationship between ultrasound-guided fluid resuscitation strategies and usual care in septic shock. Methods We searched PubMed, Embase, Cochrane …

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Bone marrow-derived mesenchymal stem cells overexpressed with miR-182-5p protects against brain injury in a mouse model of cerebral ischemia

Mingyang Deng, Jianyang Liu, Jialin He, Ziwei Lan et autres

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Mesenchymal Stem Cells Inhibit the Effects of Dexamethasone in Multiple Myeloma Cells

Mingyang Deng, Huan Yuan, Hongling Peng, Sufang Liu et autres

Mesenchymal stem cells (MSCs) participate in the occurrence and development of multiple myeloma. This study is aimed at exploring whether the presence of MSCs affects dexamethasone's antitumor effects against multiple myeloma. Multiple myeloma cells (OPM-2 and RPMI8226 cells) were cocultured with MSCs …

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