Kathryn J. Moore

Atherosclerotic Cardiovascular Disease and Cancer

Anaïs Amend, Hauke Horstmann, Kory J. Lavine, Chiara Giannarelli et autres

Atherosclerotic cardiovascular disease (ASCVD) and cancer are increasingly recognized as interconnected diseases linked by shared immune mechanisms rather than merely overlapping risk factors. Common exposures such as smoking, obesity, diabetes, and dyslipidemia, together with aging and clonal hematopoiesis of indeterminate potential (CHIP), …

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Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction

Graeme J. Koelwyn, Sayyed Hamed Shahoei, Courtenay Graham, Geoffrey M. Nonis et autres

BACKGROUND: Exercise links with improved cancer outcomes following a diagnosis of primary breast cancer but experimental evidence and molecular mechanistic interrogation from preclinical studies are limited. The purpose of this study was to evaluate the effects, and dose‒response, of exercise in mouse …

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Non-coding RNAs in lipid metabolism and their roles in atherosclerosis

Tamer Sallam, Coen V Solingen, Kathryn J. Moore

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From Vulnerability to Hope: Experiences with COVID-19 over Time in Rural America

Yodit Denu, Kathryn J. Moore, DenYelle Baete Kenyon, Susan E. Puumala et autres

Background/Objectives: The COVID-19 pandemic has impacted rural communities in unique ways. Those living in rural communities encounter several challenges in managing the effects of COVID-19, and exploring the perceptions of those from rural communities provides valuable information about rural health behaviors. This …

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Dual C3 Blockade Promotes Effective Allograft Accommodation in Sensitized Nonhuman Primate Recipients, yet Escalating DSA Trigger Late Complement-Independent Rejection

Ilhame Anwar, Isabel F. DeLaura, Joseph M. Ladowski, Janghoon Yoon et autres

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Cancer Development in Atherosclerotic Cardiovascular Disease

Jessie M. Dalman, Kathryn J. Moore

•CVD impacts cancer onset and progression, yet the underlying mechanisms remain unclear.•Cardiac-secreted factors, altered hematopoiesis, and innate immune changes link atherosclerotic CVD to cancer promotion.•Addressing common risk factors, enhancing surveillance, and targeting inflammation in CVD patients may improve cancer outcomes.

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Ischemic Injury Drives Nascent Tumor Growth Via Accelerated Hematopoietic Aging

Alexandra A. C. Newman, José Gabriel Barcia Durán, Richard Von Itter, Jessie M. Dalman et autres

BACKGROUND: Patients with peripheral artery disease have an increased risk of cancer development. Aging-associated changes in hematopoietic stem and progenitor cells (HSPCs), including inflammation and increased myelopoiesis, are implicated in both cardiovascular disease and cancer, but their contributions to cardiovascular disease-driven tumor …

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Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production

Arlette A Kasongo, Viyashini Vijithakumar, Khaled S. Abd‐Elrahman, Radhika Prabhune et autres

The mammalian brain is the most cholesterol-rich organ of the body, relying on in situ de novo cholesterol synthesis. Maintaining cholesterol homeostasis is crucial for normal brain function. Oxysterol-binding protein (OSBP)-related proteins (ORPs) are highly conserved cytosolic proteins that coordinate lipid homeostasis …

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Insights Into Heart-Tumor Interactions in Heart Failure

Tal Caller, Kathryn J. Moore, Lorenz Lehmann, Sean M. Wu et autres

Heart failure (HF) often coexists with cancer. Beyond the known cardiotoxicity of some cancer treatments, HF itself has been associated with increased cancer incidence. The 2 conditions share common risk factors, mechanisms, and interactions that can worsen patient outcomes. The bidirectional relationship …

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Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging

Alexandra A. C. Newman, José Gabriel Barcia Durán, Richard Von Itter, Jessie M. Dalman et autres

Background: Patients with peripheral artery disease have increased risk of cancer development. Aging-associated changes in hematopoietic stem and progenitor cells (HSPCs), including inflammation and increased myelopoiesis, are implicated in both cardiovascular disease (CVD) and cancer, but their contributions to CVD-driven tumor progression …

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Abstract Tu0028: Regulation of Atherosclerotic Cardiovascular Disease by Long Noncoding RNA IRF1-AS1

Morgane Gourvest, Alexandra A. C. Newman, Tracy Yuanfan Zhang, Kristin M. Wang et autres

A major cause of cardiovascular disease is atherosclerosis, a condition in which imbalances in lipid metabolism and maladaptive immune responses drive chronic inflammation in the artery wall resulting in plaque formation. Investigating the molecular mechanisms underlying persistent atherosclerotic inflammation may identify novel …

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Abstract Tu0031: The Irg1/itaconate metabolic axis rewires bone marrow myeloid progenitors in atherosclerosis

Tarik Zahr, Fazli K. Bozal, José Gabriel Barcia Durán, Michael A. Gildea et autres

Atherosclerotic cardiovascular disease (ASCVD) is accompanied by systemic inflammation, including changes in circulating immune cells and their hematopoietic progenitors. Hypercholesterolemia and western diet (WD) have been shown to induce epigenetic and metabolic reprogramming of myeloid progenitors and monocytes in the bone marrow …

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