2026
conference-abstract
OpenAlex
Hanxiao Wan, Joshua L. Katz, Yotam D. Hahn, Si Wang et autres
Abstract Glioblastoma (GBM) presents a major clinical challenge due to its highly invasive nature and resistance to treatment. We previously developed Bvax, a novel B-cell-based cancer therapy. In preclinical models of GBM, Bvax elicited robust antitumor immunity by enriching a subpopulation of …
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Accès ouvert
2026
article
OpenAlex
Leah K. Billingham, Susan L DeLay, Yasmina Eshac, Tzu-Yi Chia et autres
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors in adults. Its immune microenvironment is dominated by tumor-associated macrophages, including both infiltrating monocytes and brain-resident microglia. While metabolic rewiring of infiltrating myeloid cells has been shown to support tumor …
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2026
article
OpenAlex
Grace Jones, Alina R Murphy, Catalina Lee-Chang
Arising from extracranial cancers, brain metastases (BrM) are the most prevalent brain malignancy in adults. Even though there are recent advances in systemic cancer therapies and immunotherapies, the prognosis for BrM remains poor, with median survival rather dismal. The central nervous system …
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2025
conference-abstract
OpenAlex
Tzu-Yi Chia, Chao Wei, Leah K. Billingham, Suzi Delay et autres
Abstract Although immunotherapy has transformed cancer treatment, glioblastoma (GBM) remains stubbornly resistant due to multiple immunosuppressive mechanisms. Our previous work identified polyamine metabolism as a key driver of this immunosuppression, with difluoromethylornithine (DFMO) improving survival in a T and B cell-dependent manner. …
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2025
article
OpenAlex
David Hou, Si Wang, Brandyn Castro, Joshua L. Katz et autres
Abstract Immunotherapy has revolutionized cancer treatment but remains ineffective against glioblastoma (GBM), where the immunosuppressive tumor microenvironment (TME) limits therapeutic success. While B-cells influence immune checkpoint blockade (ICB) responses in peripheral tumors, their role in GBM remains poorly understood. Here, we demonstrate …
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Accès ouvert
2025
conference-abstract
OpenAlex
Alina R Murphy, Si Wang, Gustavo Vazquez-Cervantes, Hanxiao Wan et autres
Abstract Glioblastoma (GBM) is the deadliest primary brain tumor, characterized by immunosuppression, low infiltration of lymphocytes, and lack of response to immune checkpoint blockade (ICB) therapies. In other solid tumors, the presence of functional B cells is predictive of response to ICB. …
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2025
conference-abstract
OpenAlex
Joshua Katz, Hanxiao Wan, Gustavo Vazquez-Cervantes, Si Wang et autres
Abstract Glioblastoma (GBM) presents a major clinical challenge due to its highly invasive nature and resistance to treatment. We previously developed Bvax, a novel B cell based cancer therapy. In preclinical models of GBM, Bvax elicited robust antitumor immunity by enriching a …
us, it
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Rebecca Du, Víctor A. Arrieta, Jasim K Benotbatme, Sachin Govind et autres
Abstract Chordomas are malignant notochordal remnant tumors resistant to standard therapies. Using single-cell RNA-sequencing and spatial transcriptomics, we identified that the chordoma immune landscape is marked by macrophage-rich infiltrates and T-cell dysfunction. Furthermore, we reconstructed a differentiation pathway showing that naïve and …
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Accès ouvert
2025
article
OpenAlex
David Hou, Si Wang, Brandyn Castro, Joshua L. Katz et autres
BACKGROUND: Immunotherapy has revolutionized cancer treatment but has yet to be translated into brain tumors. Studies in other solid tumors suggest a central role of B-cell immunity in driving immune checkpoint blockade efficacy. In glioblastoma (GBM), tumor B cells are driven into …
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2025
preprint
OpenAlex
Leah K. Billingham, Ian Olson, Kaylee Zilinger, Jay Subbiah et autres
Abstract Glioblastoma (GBM) is most common and aggressive primary brain tumor in adults, for which standard of care hasn’t changed in twenty years. GBM tumor associated macrophages (TAMCs), consisting of infiltrating myeloid cells from the periphery and resident microglia cells, are pro-tumorigenic, …
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Accès ouvert
2024
article
OpenAlex
Alina R Murphy, Huma Asif, Harun Cingoz, Françoise A. Gourronc et autres
CONTEXT: Obesity is a disease with deleterious effects on the female reproductive tract, including the endometrium. OBJECTIVE: We sought to understand the effects of excess adipose on the benign endometrium. METHODS: A physiologic in vitro coculture system was developed, consisting of multicellular …
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Accès ouvert
2023
article
OpenAlex
Hannes Campo, Didi Zha, Pawat Pattarawat, Jose A. Colina et autres
. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that …
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