Kun Qiao

The impact of learning modalities and sleep quality on adolescent mental health: a cross-sectional study

Li Du, Kun Qiao, Qi Liu, LeJuan Feng et autres

Background Adolescents’ mental health and sleep have been significantly affected during the COVID-19 pandemic, yet differences between home-based online learning and in-school learning remain unclear. Methods A cross-sectional survey was conducted among 5,787 students in Grades 7–12 from 14 schools in Gansu …

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H3.3 S-sulfhydration controls granulosa cell maturation by modulating Adam19-mediated FAK–ERK1/2 signaling in mice

S Y Chen, Kun Qiao, Juan Liu, Hai-Li Wu et autres

Objective: S-sulfhydration of proteins is reported to be an important downstream event in signaling mediated by H 2 S, a crucial endogenous gasotransmitter. However, studies on the role of S-sulfhydrated proteins in the ovaries are limited. In this study, we sought to …

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Multi-Omics Reveals Tetrodotoxin Transport and Accumulation Mechanisms in Takifugu bimaculatus

Xi Zhang, Min Xu, Jiapeng Qi, Shuigen Li et autres

The potent toxicity of tetrodotoxin (TTX) has long constrained sustainable growth in pufferfish aquaculture. Takifugu bimaculatus, an economically important species farmed along the coast of Fujian, China, remains poorly understood regarding how it transports and accumulates this potent neurotoxin. To address this …

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Effects and Mechanisms of Ultrasonic and Papain Treatment on Texture Properties of the Abalone (Haliotis discus hannai) Meat

Zhenhao Song, Huaqiong Li, Z Liu, Meijiao Gui et autres

meat has a firm texture that makes it difficult to chew and swallow, so tenderizing is necessary. Ultrasonic treatment and papain enzyme processing are used to reduce the hardness of abalone meat. This study tests physicochemical indicators and protein changes to assess …

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Identification of TRPV1-Inhibitory Peptides from Takifugu fasciatus Skin Hydrolysate and Their Skin-Soothing Mechanisms

Bei Chen, Dong Zhang, Ray‐Shyan Wu, Kun Qiao et autres

Skin sensitivity is increasingly prevalent, necessitating new therapeutic agents. This study screened multifunctional peptides from Takifugu fasciatus skin for transient receptor potential vanilloid 1 (TRPV1)-inhibitory and anti-inflammatory activities and investigated their mechanisms in alleviating sensitive skin (SS). A low-molecular-weight hydrolysate was prepared …

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Impact of Steam Processing on the Physicochemical Properties and Flavor Profile of Takifugu flavidus: A Comprehensive Quality Evaluation

Xiaoting Chen, Bei Chen, Yinghong Qu, Ray‐Shyan Wu et autres

As a culturally iconic Chinese delicacy, pufferfish lacks systematic research on thermal processing optimization and pre-cooked meal development, limiting its industrial standardization and quality preservation. This study aimed to bridge this gap by evaluating steaming effects on Takifugu flavidus quality. This study …

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Comparative Analysis of the Nutritional Composition and Flavor Profile of Different Muscle Parts of Hybrid Abalone (Haliotis discus hannai ♀ × H. fulgens ♂)

Tongtong Sun, Xiaoting Chen, Zhiyu Liu, Chenyang Y. Xie et autres

This study analyzed the basic nutritional components and amino acid, fatty acid, and mineral composition of hybrid abalone Haliotis discus hannai ♀ × H. fulgens ♂ adductor (AM), transition (TM), and skirt (SM) muscles. The taste characteristics of the muscles were measured …

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Screening and Antioxidant Activities Evaluation of Peptides From Abalone ( Haliotis discus hannai Ino)

Jingna Wu, Xiaoya Wang, Kun Qiao, Nan Pan et autres

ABSTRACT Marine organisms are rich in antioxidant peptides; however, extracting these peptides is time‐consuming, labor‐intensive, and costly, with sequence losses leading to uncertain results. This study aimed to identify abalone‐derived antioxidant peptides with strong Keap1 binding ability and validate their antioxidative activities …

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Virtual screening and evaluation of bioactive peptides from Haliotis discus hannai as potential HMGCR inhibitors for hyperlipidemia treatment

Kun Qiao, Lina Liu, Yihui Chen, Bei Chen et autres

Introduction Hyperlipidemia remains a major disease threatening global public health. The morbidity and mortality associated with cardiovascular diseases have been increasing. The inhibition of 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in the cholesterol synthesis pathway, can effectively reduce cholesterol levels. Methods …

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Preparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources

Kun Qiao, Tongtong Sun, Bei Chen, Yongchang Su et autres

Marine-derived foods, often called blue foods, are promising sustainable alternatives to conventional food sources owing to their abundant amino acids and high protein content. Current treatments for hyperuricemia, a chronic condition attributed to purine metabolism disorders, are associated with various side effects. …

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Sonocatalysis-responsive nanodrug platforms for radioimmunotherapy against breast cancer

Kun Qiao, Mingzhu Chen, Meng Lyu, Xingda Zhang et autres

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Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu et autres

Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms. Because of this and the lack of specific antidotes, TTX poisoning is now a major threat to public …

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