Heli Rajasaar

Transmitted HIV-1 drug resistance in Estonian residents and Ukrainian refugees in 2020 and 2022

Arina Šablinskaja, Hiie Soeorg, Merit Pauskar, Ene‐Ly Jõgeda et autres

OBJECTIVES: We investigated the prevalence of drug resistance mutations (DRMs) in individuals newly diagnosed with HIV-1 in Estonia in 2020 and 2022, and in Ukrainian war refugees living with HIV who arrived in Estonia in 2022. METHODS: HIV-1 genomic RNA was sequenced …

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No transmitted drug resistance to HIV integrase strand-transfer inhibitors after their scale-up in Estonia in 2017

Arina Šablinskaja, Merit Pauskar, Ene‐Ly Jõgeda, Heli Rajasaar et autres

OBJECTIVES: In Eastern Europe, HIV-1 transmitted drug resistance (TDR) data, especially in the integrase (IN) region, are limited. In Estonia, INSTI (integrase strand transfer inhibitors) TDR has been studied only prior to the INSTI scale-up in late 2010s. The current study aimed …

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Early Impact of Severe Acute Respiratory Syndrome Coronavirus 2 on Pediatric Clinical Research: A Pan-European and Canadian Snapshot in Time

Olivier L. Mantha, Florence Flamein, M. Turner, Ricardo M. Fernandes et autres

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Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study

Kerstin Kase, Radko Avi, Karolin Toompere, Heli Rajasaar et autres

BACKGROUND: Estonia has a typical Eastern European HIV epidemic where the most frequent co-infection is chronic hepatitis C (HCV). We aimed to describe the changes in HCV prevalence, the distribution of HCV genotypes (GT), and HCV treatment in Estonian people living with …

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Dynamics of hepatitis C epidemic among people living with HIV in Estonia

Kerstin Kase, Radko Avi, Karolin Toompere, Heli Rajasaar et autres

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Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy

Pilleriin Soodla, Kristi Huik, Merit Pauskar, Lize Cuypers et autres

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The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx

Kristi Huik, Pilleriin Soodla, Merit Pauskar, S. Michele Owen et autres

BACKGROUND: Serological assays to determine HIV incidence have contributed to estimates of HIV incidence, monitoring of HIV spread, and evaluation of prevention strategies. Two frequently used incidence assays are the Sedia HIV-1 LAg-Avidity EIA (LAg) and the Bio-Rad avidity incidence (BRAI) assays …

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HIV incidence in the Estonian population in 2013 determined using the HIV ‐1 limiting antigen avidity assay

Pilleriin Soodla, Ruth Simmons, Kristi Huik, Mahendra Manoj Pauskar et autres

OBJECTIVES: Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV infection testing algorithm …

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Design and structure of the Estonian HIV Cohort Study (E-HIV)

Pilleriin Soodla, Heli Rajasaar, Radko Avi, Kai Zilmer et autres

BACKGROUND: Estonia is experiencing the new Eastern Europe human immunodeficiency virus (HIV) epidemic, with the highest incidence of new infections in the EU. We describe demographic changes, HIV-related laboratory parameters and co-infections during the concentrated HIV epidemic using the Estonian HIV Cohort …

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Co-infection with hepatitis C virus (HCV) in Estonian intravenous drug users HIV epidemic

Kristi Huik, Heli Rajasaar, Radko Avi, Merit Pauskar et autres

Estonian concentrated HIV epidemic started in August 2000 when rare HIV-1 CRF06_cpx was introduced into the population of intravenous drug users (IDUs). The majority of these HIV-positive subjects are likely co-infected with HCV but the prevalence of HCV and its genotypes during …

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