Hiroshi Miura

A multidimensional analysis of CGM-derived glucose metrics in type 1 diabetes: differential associations of insulin degludec and insulin glargine U300

Kazuhiko Sakaguchi, Hikaru Sugimoto, Hiroshi Miura, Tomoko Yamada et autres

Ultra-long-acting basal insulins, insulin degludec (IDeg) and insulin glargine U300 (IGlarU300), are widely used in type 1 diabetes mellitus (T1DM), but their differential effects on multidimensional continuous glucose monitoring (CGM) profiles remain unclear. We aimed to identify latent dimensions underlying CGM-derived metrics …

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Anthropometry-adjusted TyG indices improve insulin resistance estimation: an exploratory euglycemic–hyperinsulinemic clamp study in Japanese adults without diabetes

Natsu Otowa-Suematsu, Tomoaki Nakamura, Hiroshi Miura, Tomoko Yamada et autres

Background: We evaluated the diagnostic performance of anthropometry-adjusted triglyceride-glucose (TyG)-derived indices for assessing insulin resistance (IR) in Japanese adults without diabetes, using the euglycemic-hyperinsulinemic clamp (EHC) as the reference standard. Methods: A total of 61 Japanese individuals without diabetes underwent insulin sensitivity …

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Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices

Hikaru Sugimoto, Ken‐ichi Hironaka, Tomoaki Nakamura, Tomoko Yamada et autres

Efficiently assessing glucose handling capacity is a critical public health challenge. This study assessed the utility of relatively easy-to-measure continuous glucose monitoring (CGM)-derived indices in estimating glucose handling capacities calculated from resource-intensive clamp tests. We conducted a prospective study of 64 individuals …

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Mathematical Models of the Effect of Glucagon on Glycemia in Individuals With Type 2 Diabetes Treated With Dapagliflozin

Tomoko Yamada, Hikaru Sugimoto, Ken‐ichi Hironaka, Yasuko Morita et autres

Abstract Context Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower blood glucose levels by promoting urinary glucose excretion, but their overall effects on hormonal and metabolic status remain unclear. Objective We here investigated the roles of insulin and glucagon in the regulation of glycemia …

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Improved Detection of Decreased Glucose Handling Capacities via Novel Continuous Glucose Monitoring-Derived Indices: AC_Mean and AC_Var

Hikaru Sugimoto, Ken‐ichi Hironaka, Tomoaki Nakamura, Tomoko Yamada et autres

ABSTRACT Background Efficiently detecting impaired glucose control abilities is a pivotal challenge in public health. This study assessed the utility of relatively easy-to-measure continuous glucose monitoring (CGM)-derived indices in estimating glucose handling capacities calculated from resource-intensive clamp tests. Methods We conducted a …

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Preoperative Serum Cortisol Level Is Predictive of Weight Loss After Laparoscopic Sleeve Gastrectomy in Men with Severe Obesity but Not Women

Hironori Bando, Hiroshi Miura, Seiichi Kitahama, Shinsuke Nakajima et autres

BACKGROUND: Bariatric surgery is an effective treatment for severe obesity and its associated medical problems. Preoperative factors that predict postoperative weight loss remain to be fully characterized, however. METHODS: Anthropometric and laboratory data were collected retrospectively for severely obese patients who underwent …

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Successful Resolution of Glucose Toxicity With the Use of Fixed-Ratio Combination Injection of Basal Insulin and Short-Acting Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist

Hiroshi Miura, Naokazu Muramae, Kenta Mori, Kazunori Otsui et autres

Chronic hyperglycemia leads to a decrease in glucose-stimulated insulin secretion and an increase in insulin resistance. Resolving these glucose toxicities is pivotal in type 2 diabetes therapy because the decline in insulin secretion and insulin sensitivity causes further hyperglycemia. Conventionally, multiple daily …

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Clinical features of 65‐year‐old individuals in Japan diagnosed with possible sarcopenia based on the Asian Working Group for Sarcopenia 2019 criteria

Hiroshi Miura, Kazuhiko Sakaguchi, Wataru Ogawa, Yoshikazu Tamori

AIM: The prevalence of sarcopenia and the health status of affected individuals, particularly among the young elderly, are unclear in Japan. We determined the prevalence of possible sarcopenia, a concept proposed by the Asian Working Group for Sarcopenia (AWGS) in 2019, and …

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Relation of cardiac function to insulin resistance as evaluated by hyperinsulinemic‐euglycemic clamp analysis in individuals with type 2 diabetes

Natsu Otowa‐Suematsu, Kazuhiko Sakaguchi, Akihiro Kaneko, Jun Ito et autres

AIMS: Whereas homeostasis model assessment of insulin resistance (HOMA-IR), an easily measured but limited index of insulin resistance, has been shown to correlate with impairment of cardiac function in individuals without diabetes, the pathological relevance of insulin resistance to the development of …

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Sex difference in the association of obesity with personal or social background among urban residents in Japan

Shun‐ichiro Asahara, Hiroshi Miura, Wataru Ogawa, Yoshikazu Tamori

The development of obesity is influenced by genetic and environmental factors and is associated with a variety of health problems. To gain insight into environmental factors that contribute to obesity, we analyzed the relation of personal or social background to obesity in …

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Analysis of time-dependent alterations of parameters related to erythrocytes after ipragliflozin initiation

Tomoko Yamada, Kazuhiko Sakaguchi, Yuko Okada, Hiroshi Miura et autres

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Effects of insulin degludec and insulin glargine U300 on glycaemic stability in individuals with type 1 diabetes: A multicentre, randomized controlled crossover study

Hiroshi Miura, Kazuhiko Sakaguchi, Natsu Otowa‐Suematsu, Tomoko Yamada et autres

To compare the effects of insulin degludec (IDeg) and insulin glargine U300 (IGlarU300) on glycaemic stability in subjects with type 1 diabetes. MATERIALS AND METHODS: In this multicentre, crossover trial, 46 individuals with type 1 diabetes and essentially undetectable circulating C-peptide were …

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