Eleonora Zanetti

ANTHROPOLOGY, COMPLEXITY AND THE LIMITS OF TOP-DOWN CONFLICT ANALYSIS

Eleonora Zanetti

Conflict analysis often approaches violence through externally defined categories, scales, and institutional frameworks that simplify complex social relations into identifiable problems and corresponding interventions. Similarly, contemporary localization paradigms seek to bring analysis, decision-making, and intervention closer to affected communities. Yet treating “the …

Abstract C045: Exploring EGLN1/PHD2 role in KRAS mutated lung cancer: insights into mitochondrial modulation and therapeutic opportunities

A Grieco, Giulio Verna, Silvia Strocchi, Valentina Fantini et autres

Abstract Lung cancer is the first cause of cancer-related death. In lung adenocarcinoma (LUAD), different genetic alterations can be targeted with small-molecule compounds, including the KRAS inhibitors. However, the development of resistance mechanisms indicates that exploring new target genes is still an …

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Shocks and Cultural Adaptations: A Case Study From Northern Kenya

Eleonora Zanetti

This paper examines how the Rendille pastoralists of Northern Kenya navigate environmental and political shocks, offering insights into governance and resilience from below. Drawing on ethnographic fieldwork, it shows how legal pluralism, patronage networks, and culturally grounded adaptation strategies shape responses to …

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Metastatic Carcinomas at the Episiotomy Site: A Systematic Literature Review

Andrea Palicelli, Gabriele Tonni, Federica Torricelli, Beatrice Melli et autres

Background/Objectives: Rarely, primary (PriCs) or metastatic (metECs) carcinomas occur in the episiotomy site. Methods: A systematic literature review of metECs was carried out. We reviewed the PRISMA guidelines and the Scopus, Pubmed, and Web of Science databases. Results: We found 21 carcinomas; …

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A Partial Hydatidiform Mole in an Ovarian Ectopic Pregnancy: An Exceptional Occurrence

Maria Paola Bonasoni, Roberta Zuntini, Loredana De Marco, Eleonora Zanetti et autres

Background and Clinical Significance: Ovarian ectopic pregnancy (OEP) is a rare occurrence, and molar degeneration is even more exceptional. Differential diagnosis between a partial and complete hydatidiform mole is paramount as the complete type carries a higher risk of post-molar gestational trophoblastic …

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Primary Carcinomas of the Episiotomy Scar Site: A Systematic Literature Review

Andrea Palicelli, Federica Torricelli, Gabriele Tonni, Alessandra Bisagni et autres

Episiotomy is a perineal incision enlarging the vaginal opening during labor, preventing severe perineal/vaginal/ano-rectal lacerations. We performed a systematic literature review (PRISMA guidelines; Pubmed, Scopus and Web of Science databases) of primary malignant tumors arising from the episiotomy site. Thirteen primary carcinomas …

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A Two-Step Protocol for Isolation and Maintenance of Lung Cancer Primary 3D Cultures

Silvia Strocchi, Giacomo Santandrea, Eleonora Zanetti, Giulio Verna et autres

BACKGROUND/OBJECTIVES: Despite the introduction of innovative therapeutics, lung cancer is still the leading cause of cancer-related death. For this reason, lung cancer still requires deep characterization to identify cellular and molecular targets that can be used to develop novel therapeutic strategies. Three-dimensional …

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Digital spatial profiling for pathologists

Benedetta Donati, Gloria Manzotti, Federica Torricelli, Cristian Ascione et autres

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Evaluation of the immune landscape associated with the efficacy of immunotherapy in patients with triple-negative breast cancer: Starlet study, synergy between research and clinical work.

Elisa Gasparini, Moira Ragazzi, Gloria Manzotti, Federica Torricelli et autres

e12568 Background: Neoadjuvant chemotherapy (NACT) is the standard treatment for early-stage TNBC and achieving a pathological complete response (pCR) is an essential prognostic factor. Recently, by applying a morphology-guided spatial transcriptomic approach, we showed that intratumoral infiltrating lymphocytes (iTILs) and stromal Natural …

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Abstract PO2-25-03: Deciphering the immune molecular signature associated with pembrolizumab efficacy in the neoadjuvant setting of Triple-Negative Breast Cancer patients: a single-centre experience

Elisa Gasparini, Gloria Manzotti, Moira Ragazzi, Benedetta Donati et autres

Abstract Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and is characterized by a high rate of recurrence, despite the improvement of the therapeutic approaches in recent years. Neoadjuvant chemotherapy (NACT) is the standard treatment for early-stage TNBC. Achieving …

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BET inhibitors drive Natural Killer activation in non-small cell lung cancer via BRD4 and SMAD3

Francesca Reggiani, Giovanna Talarico, Giulia Gobbi, Elisabetta Sauta et autres

Non-small-cell lung carcinoma (NSCLC) is the most common lung cancer and one of the pioneer tumors in which immunotherapy has radically changed patients' outcomes. However, several issues are emerging and their implementation is required to optimize immunotherapy-based protocols. In this work, we …

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The long non-coding RNA TAZ-AS202 promotes lung cancer progression via regulation of the E2F1 transcription factor and activation of Ephrin signaling

Giulia Gobbi, A Grieco, Federica Torricelli, Elisabetta Sauta et autres

Long non-coding RNAs (lncRNAs) are transcripts without coding potential that are pervasively expressed from the genome and have been increasingly reported to play crucial roles in all aspects of cell biology. They have been also heavily implicated in cancer development and progression, …

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