ALESSIA ERIKA RUSSO

Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy

Luca Boscolo Bielo, Stefania Napolitano, Antonio Avallone, F. Pietrantonio et autres

Background Translational studies have provided evidence that targeted therapies and chemotherapy might induce a status of adaptive mutability with an increase in the tumor mutational load. Patients and methods We conducted an analysis of pathogenic variants (PVs) detected by liquid biopsy (LBx)-based …

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Integrating tissue and liquid biopsy comprehensive genomic profiling to predict efficacy of anti-EGFR therapies in metastatic colorectal cancer: Findings from the CAPRI-2 GOIM study

Davide Ciardiello, Luca Boscolo Bielo, Stefania Napolitano, Eleonora Cioli et autres

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Comprehensive genomic profiling by liquid biopsy portrays metastatic colorectal cancer mutational landscape to predict antitumor efficacy of FOLFIRI plus cetuximab in the CAPRI-2 GOIM trial

Davide Ciardiello, Luca Boscolo Bielo, Stefania Napolitano, T. Latiano et autres

BACKGROUND: Limited evidence is currently available on the role of liquid biopsy (LBx) in predicting the efficacy of anti-epidermal growth factor receptor (EGFR) therapies in metastatic colorectal cancer (mCRC). METHODS: The CAPRI-2 GOIM is a phase II trial investigating the use of …

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1655P Association of location of BRCA1/2 pathogenic variants with benefit from PARP-inhibitors in metastatic castration-resistant prostate cancers: Results from the PROGRESS study

Lorena Incorvaia, Marco Maruzzo, Umberto Basso, L. Antonuzzo et autres

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Comprehensive genomic profiling by liquid biopsy captures tumor heterogeneity and identifies cancer vulnerabilities in patients with RAS/BRAFV600E wild-type metastatic colorectal cancer in the CAPRI 2-GOIM trial

Davide Ciardiello, Luca Boscolo Bielo, S. Napolitano, E. Martinelli et autres

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Correlation between metastatic site and immunotherapy efficacy in patients with advanced dMMR/MSI colorectal cancer: Real-World Italian multicentric retrospective study (Colon-MSI).

Francesco Iachetta, Chiara Cremolini, Giamaica Ciardiello, Angela Damato et autres

e15544 Background: Immune checkpoint inhibitors (ICIs) are the gold standard therapy in metastatic colorectal cancer (mCRC) patients (pts) with microsatellite instability (MSI). The Colon-MSI study aimed to describe a cohort of MSI mCRC pts treated with ICIs before Italian pembrolizumab approval and …

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CAROTID–FEMORAL PULSE WAVE VELOCITY PROGRESSION IN HYPERTENSIVE PATIENTS IS ASSOCIATED WITH SUBSEQUENT CV OUTCOMES

A Maloberti, Paola Rebora, Giuseppe Occhino, Anita Andreano et autres

Abstract Objective Arterial stiffness (Pulse Wave Velocity – PWV) is associated with CV events and mortality. However, little is known on the relationship of its progression (ΔPWV) over time with CV outcomes. The aim of our study was to evaluate the relationship …

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Intergenerational Insurance

Francesco Lancia, ALESSIA ERIKA RUSSO, Tim S. Worrall

How should successive generations insure each other when the young can default on previously promised transfers to the old? This paper studies intergenerational insurance that maximizes the expected discounted utility of all generations subject to participation constraints for each generation. If complete …

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On the Effectiveness of Gendering Politics

Arcangelo Dimico, Francesco Lancia, ALESSIA ERIKA RUSSO

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Supplementary Figure S1 from Shorter Leukocyte Telomere Length Is Independently Associated with Poor Survival in Patients with Bladder Cancer

ALESSIA ERIKA RUSSO, Federica Modica, Simonetta Guarrera, Giovanni Fiorito et autres

Supplementary Figure S1. Kaplan-Meier OS curves of bladder cancer patients stratified for TL quartiles. OS, overall survival; TL, telomere length.

Supplementary Table S3 from Shorter Leukocyte Telomere Length Is Independently Associated with Poor Survival in Patients with Bladder Cancer

ALESSIA ERIKA RUSSO, Federica Modica, Simonetta Guarrera, Giovanni Fiorito et autres

Supplementary Table S3. Multivariate Cox regression survival analysis, including TL, age, TG, BCG, radical cystectomy, radiotherapy and chemotherapy. All cause of death.

Supplementary Table S2 from Shorter Leukocyte Telomere Length Is Independently Associated with Poor Survival in Patients with Bladder Cancer

ALESSIA ERIKA RUSSO, Federica Modica, Simonetta Guarrera, Giovanni Fiorito et autres

Supplementary Table S2. TL quartiles and OS association analysis (Crude Cox regression).