Anil Tiwari

Kuragel—liquid cornea: A bioengineered solution for corneal blindness

Parinita Agrawal, Abha Gour, Mehak Sapra, Anil Tiwari et autres

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Contributors

Carla J. Abbott, Anas Abu-Dieh, Parinita Agrawal, Penelope J. Allen et autres

Tear Cytokine Signature in Vernal Keratoconjunctivitis: A Chemokine-Remodeling Axis Associated with Disease Severity

Kartik Goel, Mehak Sapra, Prisha Warikoo, Shailja Tibrewal et autres

Vernal keratoconjunctivitis (VKC) is a chronic pediatric ocular allergy that can progress from seasonal to persistent inflammation with vision-threatening complications. Although Th2-associated mechanisms have been implicated, the immune correlates of disease severity are not well defined. Tear samples from VKC patients (moderate …

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Surgical interventions in herpes simplex virus keratitis: Outcomes in a large cohort

Aastha Garg, Kajal Singh, Manisha Acharya, Anil Tiwari et autres

PURPOSE: Herpes simplex virus (HSV) keratitis is a significant cause of infectious corneal morbidity worldwide. Severe cases may require surgical intervention when medical therapy fails. This study evaluates surgical outcomes in managing advanced HSV keratitis. METHODS: This was a retrospective observational cohort …

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LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma

Aman Verma, Sugam Kumar Patel, Akhil Varshney, Pratyashaa Paul et autres

Abstract Retinoblastoma (RB), the most common pediatric intraocular malignancy, is initiated by biallelic inactivation of the RB1 tumor suppressor gene. Although LINE-1 (L1) retrotransposon activation has been linked to genomic instability and tumor evolution in several adult cancers, its contribution to pediatric …

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Higher versus Routine Intraoperative Blood Pressure Targets in Noncardiac Surgery: A Systematic Review and Meta-analysis with Trial Sequential Analysis of Randomized Trials

Katie Chiou, Sovann Vikram, Kiana Rowshan, Smeet Shah et autres

BACKGROUND: Observational studies consistently link intraoperative hypotension to adverse postoperative outcomes, leading guidelines to recommend maintaining mean arterial pressure 60 to 65 mmHg or greater during noncardiac surgery. Whether targeting higher intraoperative blood pressure values improves clinical outcomes remains uncertain. METHODS: The …

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Opioid-Free Anesthesia Versus Opioid-Based Anesthesia for Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Katie Chiou, Dylan Mai, Anil Tiwari, Phat M. Dang et autres

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Trefoil Factor 1 (TFF1) in Retinoblastoma: A Biomarker, Mediator, or Therapeutic Target?

Aman Verma, Mohak Kapoor, Tanish Soni, Sima Das et autres

Retinoblastoma is a prevalent pediatric malignant tumour of the retina, primarily caused by biallelic inactivation of the RB1 gene or, less commonly, amplification of the MYCN oncogene. It has a global incidence of approximately 1 in 15,000–18,000 live births and predominantly affects …

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Tear Cytokine Profiling in Vernal Keratoconjunctivitis Identifies Immune Signatures Associated with Disease Severity

Kartik Goel, Prisha Warikoo, Abha Gour, Shailja Tibrewal et autres

Background: Vernal keratoconjunctivitis (VKC) is a chronic pediatric ocular allergic disease that can progress from seasonal to persistent inflammation with vision-threatening complications. While Th2 mechanisms are implicated, immune correlates of disease severity remain unclear. Methods: Tear samples from VKC patients (moderate intermittent …

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Regulation of immunological equilibrium by IL-6/STAT3 in glaucomatous irises and its effect on filtering bleb success

Nisha Sinha, Suneeta Dubey, Julie Pegu, Virender Singh Sangwan et autres

PURPOSE: To investigate the expression of interleukin-6 (IL-6) and its associated downstream genes within iris tissues of primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), and secondary glaucoma (neovascular, traumatic, and uveitic) subjects, assess cytokines correlation and their influence on trabeculectomy success. …

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Corneal Microstructural Alterations in Vernal Keratoconjunctivitis and Keratoconus Assessed by In Vivo Confocal Microscopy

Bharti Sangwan, Jyoti Sangwan, Amulya Thatigotla Naga, Jyoti Rajput et autres

Deciphering the Role of Alu cDNA in Driving Retinal Angiogenesis

Aman Verma, Mehak Sapra, Akhil Varshney, Virender Singh Sangwan et autres

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