Marzena Anna Lewandowska

Association of Selected miRNAs (hsa-miR-27b, hsa-miR-128-3p, hsa-miR-145-5p, hsa-miR-552-3p) with HER2 Status and Chromosome 17 Centromere Copy Number Increase in Gastric Cancer

Maciej Ciesielski, Marzena Anna Lewandowska, Mariusz Szajewski, Krzysztof Pastuszak et autres

Human epidermal growth factor receptor 2 (HER2) remains the most recognized and clinically established molecular biomarker in gastric cancer; however, the regulatory mechanisms underlying its dysregulation are not fully understood. This study aimed to identify microRNAs associated with HER2 gene amplification, chromosome …

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The Impact of miR-21-5p, miR-145-5p and miR-382-5p Expression in Gastric Adenocarcinoma Cells on Lymphatic Spread Capability

Maciej Ciesielski, Marzena Anna Lewandowska, Mariusz Szajewski, Krzysztof Pastuszak et autres

Objectives: miR-21-5p, miR-145-5p and miR-382-5p have been associated with angiogenesis, which plays a central role in tumor growth and metastasis formation. The aim of the study was to determine whether expression of these three potentially angiogenic miRNAs is related to the lymphatic …

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Tumor Mutational Burden in Cervical Cancer as Potential Marker for Immunotherapy Responders

Magdalena Ewa Kowalkowska, Katarzyna Kamińska, Joanna Wojtysiak, Krzysztof Koper et autres

Background/Objectives: Tumor mutational burden (TMB) has emerged as a potential biomarker of response to immunotherapy across multiple solid tumors. However, its role in cervical cancer remains insufficiently defined. This study aimed to evaluate the genomic landscape and TMB profile in a cohort …

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Whole-miRNome sequencing: a panel for the targeted sequencing of all human miRNA genes

Paulina Galka-Marciniak, Martyna Olga Urbanek-Trzeciak, Daniel Kuźnicki, Natalia Szóstak et autres

Interest in the genetic variation of noncoding genomic elements, including microRNAs (miRNAs), is growing, and several mutations in miRNA genes implicated in human diseases, including cancer, have already been detected. However, the lack of dedicated analytical tools severely hampers progress in this …

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Whole-miRNome sequencing (WMS) - a panel for targeted sequencing of all human miRNA genes

Paulina Galka-Marciniak, Martyna Olga Urbanek-Trzeciak, Daniel Kuźnicki, Natalia Szóstak et autres

ABSTRACT There is a growing interest in the genetic variation of noncoding genomic elements, including miRNAs, and several mutations in miRNA genes implicated in human diseases, including cancer, have already been detected. However, the lack of dedicated analytical tools severely hampers progress …

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Nodal form of Rosai-Dorfman-Destombes disease

Oliwia Grochowska, Kamila Jaremek, Agnieszka Majk, Przemysław Gałązka et autres

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Clinical Validation of GenBody COVID-19 Ag, Nasal and Nasopharyngeal Rapid Antigen Tests for Detection of SARS-CoV-2 in European Adult Population

Karolina Węgrzyńska, Jarosław Walory, Radosław Charkiewicz, Marzena Anna Lewandowska et autres

Accurate and rapid identification of COVID-19 is critical for effective patient treatment and disease outcomes, as well as the prevention of SARS-CoV-2 transmission. Rapid antigen tests (RATs) for identifying SARS-CoV-2 are simpler, faster and less expensive than molecular assays. Any new product …

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Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics

Paulina Śledzińska, Marek Bebyn, Ewelina Szczerba, Jacek Furtak et autres

INTRODUCTION: The accurate detection of genetic variants such as single substitutions (IDH1/2, TERT), chromosomal abnormalities (CDKN2A, 1p/19q deletions, and EGFR amplifications), or promoter methylations (MGMT) is critical for glioma patient management, as emphasized in the World Health Organization's (WHO's) most recent classification …

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HPV RNA and DNA testing in Polish women screened for cervical cancer – A single oncological center study

Marek Bebyn, Paulina Śledzińska, Joanna Wojtysiak, Wojciech Jóźwicki et autres

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Prognostic and Predictive Biomarkers in Gliomas

Paulina Śledzińska, Marek Bebyn, Jacek Furtak, Janusz Kowalewski et autres

Gliomas are the most common central nervous system tumors. New technologies, including genetic research and advanced statistical methods, revolutionize the therapeutic approach to the patient and reveal new points of treatment options. Moreover, the 2021 World Health Organization Classification of Tumors of …

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1 Personalized and targeted therapies

M. Wisniewska, Michał Wiśniewski, Marzena Anna Lewandowska

Biomarker is defined as indicator of normal or pathogenic biological process or response to an intervention or exposure. There are several categories of biomarkers but predictive biomarkers play the most important role in the treatment of neoplasms. In some cancers there may …

Personalized and targeted therapies

Magdalena Wiśniewska, Michał Wiśniewski, Marzena Anna Lewandowska

Abstract Biomarker is defined as indicator of normal or pathogenic biological process or response to an intervention or exposure. There are several categories of biomarkers but predictive biomarkers play the most important role in the treatment of neoplasms. In some cancers there …

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