Accès ouvert
2026
article
OpenAlex
Mathilde Leboutte, Élise Rebollo, Chloé Pangault, David Ribet et autres
Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was …
fr
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Accès ouvert
2026
conference-abstract
OpenAlex
Mathilde Leboutte, Élisabeth Chatel, Christine Bôle‐Feysot, Frédéric Jaisser et autres
Abstract Background Intestinal fibrosis is a key therapeutic challenge in the management of inflammatory bowel diseases (IBD) due to the lack of anti-fibrotic therapies. Recently, we reported that genetic deletion of mineralocorticoid receptor (MR) in smooth muscle cells (SMCs) alleviated intestinal fibrosis …
fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, V. Dreux et autres
Abstract Rationale Patients with class III obesity often suffer from irritable bowel syndrome (IBS) while obesity and IBS share common pathophysiological mechanisms such as altered intestinal barrier function and gut microbiota dysbiosis. Oral glutamine (Gln) supplementation previously showed beneficial effects on gut …
fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Asma Amamou, Mathilde Leboutte, J. Breton, David Ribet et autres
Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid receptor antagonism in intestinal fibrosis. Here we show that pharmacological or smooth …
fr
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Accès ouvert
2025
article
OpenAlex
V. Dreux, Candice Lefebvre, Charles-Edward Breemeersch, Colin Salaün et autres
Sex differences in rodent models of diet-induced obesity are still poorly documented, particularly regarding how central mechanisms vary between sexes in response to an obesogenic diet. Here, we wanted to determine whether obese phenotype and hypothalamic response to a high-fat diet (HFD) …
fr
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Accès ouvert
2025
article
OpenAlex
Gaofeng Zhu, Blaise Didry‐Barca, Luís Seabra, Gillian Rice et autres
BACKGROUND: Through the agnostic screening of patients with uncharacterised disease phenotypes for an upregulation of type I interferon (IFN) signalling, we identified a cohort of individuals heterozygous for mutations in PTPN1, encoding the protein-tyrosine phosphatase 1B (PTP1B). We aimed to describe the …
gb, fr, de, us, cz, it, si, il
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Accès ouvert
2025
preprint
OpenAlex
Colin Salaün, Marion Hure, Charlene Guerin, Christine Bôle‐Feysot et autres
Abstract Rationale A role for the microbiota-gut-brain axis in the pathophysiology of anorexia nervosa (AN) has emerged in the last decade. An alteration of intestinal Toll-like receptor type 4 (TLR4) has been reported in the activity-based anorexia (ABA) model with an increase …
fr
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Accès ouvert
2025
article
OpenAlex
Léa Loison, Marion Huré, Benjamin Lefranc, Jérôme Leprince et autres
Gut bacteria play key roles in intestinal physiology, via the secretion of diversified bacterial effectors. Many of these effectors remodel the host proteome, either by altering transcription or by regulating protein post-translational modifications. SUMOylation, a ubiquitin-like post-translational modification playing key roles in …
fr
(code pays fourni par la source)
2025
article
OpenAlex
Athanasia Stoupa, Dulanjalee Kariyawasam, Fabienne Jabot‐Hanin, Adrien Nguyen Quoc et autres
CONTEXT: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and is chiefly caused by thyroid dysgenesis (CHTD). The inheritance mode of the disease remains complex. OBJECTIVE: Gain insight into the inheritance mode of CHTD. METHODS: Prospective multicenter nationwide translational study …
fr, ie, ca, ru, us, Maroc
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Mathilde Leboutte, Elena Rebollo, Céline Pangault, David Ribet et autres
Abstract Background Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition1. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of the …
fr
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Quentin Riller, Boris Sorin, Charline Courteille, Duong Ho‐Nhat et autres
IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of the IKK complex activating the canonical pathway alongside IKKβ. The absence of IKKα causes fetal encasement syndrome in humans, fatal in utero, while an impaired IKKα-NIK interaction was …
fr, be, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, V. Dreux et autres
Abstract Rationale Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. Glutamine (Gln) supplementation previously showed beneficial effects on gut barrier function and glycemic control. We thus aimed to characterize in mice the …
fr
(code pays fourni par la source)