Héctor Noguera Hurtado

Targeting GluN2B-containing NMDA receptors to interact with stress pathways and Ca2+-regulated K+ channels in murine islets of Langerhans

Héctor Noguera Hurtado, Jurek Hense, Nina Klöpper, Jana Osthues et autres

Long-term activation of NMDA receptors of pancreatic islet-cells increases oxidative stress and alters insulin secretion. Previously, we demonstrated that inhibition of GluN2B-containing NMDA receptors protects against islet-cell death. The aim of our current study was to further characterize the pathways influenced by …

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Expression and function of the NMDA receptor subunits GluN2A and GluN2B in the context of diabetes mellitus

Jana Osthues, Héctor Noguera Hurtado, Bernhard Wünsch, Martina Düfer

Question : The NMDA receptor with its various subunits is discussed as a potential target in diabetes research. We investigate whether the expression level for 2 types of the GluN2 subunit (GluN2A and 2B) varies under physiological vs. pathophysiological conditions. We also …

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NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells

Héctor Noguera Hurtado, Anne Gresch, Martina Düfer

Due to its unique features amongst ionotropic glutamate receptors, the NMDA receptor is of special interest in the physiological context but even more as a drug target. In the pathophysiology of metabolic disorders, particularly type 2 diabetes mellitus, there is evidence that …

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Acute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K+ currents.

J.R.N Martins, Samuel Campos Lopes, Héctor Noguera Hurtado, Flávia Natividade da Silva et autres

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Selective Inhibition of N-Methyl-d-aspartate Receptors with GluN2B Subunit Protects β Cells against Stress-Induced Apoptotic Cell Death

Anne Gresch, Héctor Noguera Hurtado, Laura Wörmeyer, V De Luca et autres

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