Masato Maekawa

Serum presepsin level reflects macrophage activation and hemophagocytosis in bone marrow

Katsumasa Yamanaka, Kazuki Furuhashi, Kumiko Shimoyama, Yusuke Okubo et autres

BACKGROUND: Presepsin (soluble CD14 subtype) is a clinically used diagnostic biomarker for sepsis. It is secreted into the blood by activated macrophages, and serum concentrations are elevated in patients with sepsis. Previous reports suggest that presepsin may be secreted into the peripheral …

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Fibrin-related interference as a cause of spuriously elevated thyroid hormone measurements: Genetic and acquired factors

Kenji Ohba, Yumiko Kashiwabara, Mitsuaki Tokumaru, Takayuki Iwaki et autres

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Rapid antifungal susceptibility testing for Aspergillus fumigatus using a loop-mediated isothermal amplification method

Saaya Nozue, Kazuki Furuhashi, Akihiro Toguchi, Jinko Ishikawa et autres

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Serum interferon-λ3 as a short-term biomarker of disease control in anti-MDA5-positive dermatomyositis-associated ILD

Yoshihiro Kitahara, Tomoyuki Fujisawa, Atsuki Fukada, Keigo Koda et autres

This study aimed to assess the clinical utility of serum interferon-lambda 3 (IFN-λ3) as a sequential biomarker for treatment response and disease control in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD). Serum IFN-λ3 levels were …

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Spuriously Elevated Free Thyroxine Due to Fibrin Interference in a Patient Receiving Apixaban: A Case Report and Literature Review

Takahiro Suzuki, Kenji Ohba, Akiko Agata, Shiori Takebayashi et autres

Fibrin interference can cause spurious immunoassay results, particularly in patients with coagulopathy or those receiving anticoagulant therapy. We report the case of an asymptomatic 79-year-old woman treated with apixaban, who presented spuriously elevated free thyroxine and free triiodothyronine levels, mimicking a syndrome …

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Harmonization of Lipoprotein(a) Immunoassays with the IFCC- Endorsed Reference Measurement Procedure Validated in Patient Samples and Multiple Routine testing as A Second Step Towards Apolipoprotein Standardization

Keita Yamashita, Mitsuru Wakita, Noriyasu Niizeki, Satomi Ito et autres

AIM: Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease (CVD); however, the goal of resolving its measurement issues remains unachieved. Expanding on the "first step" by Miida et al., this study evaluated the feasibility of harmonizing Lp(a) measurements using an …

jp, Ouganda, nl (code pays fourni par la source)

Glucagon change rate after glucose load: a potential key for tailoring treatment in gestational diabetes mellitus

Sae Joko, Takuya Hashimoto, Miho Yamashita, Daisuke Tsuriya et autres

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The Far Negative Intercept of the Regression Formula Obtained from Repeated Measurements of BChE and Albumin Levels is Useful for Detecting Hereditary Heterozygous Butyrylcholinesterase Deficiency in Patients on Dialysis

Naoki Tokunaga, Hisato Shima, Takuya Okamoto, Masato Maekawa et autres

Serum butyrylcholinesterase (BChE) levels are positively correlated with serum albumin levels and are influenced by inflammation. Heterozygous BChE deficiency in patients on dialysis may be overlooked as malnutrition owing to dialysis-associated low BChE and albumin levels. In this study, we aimed to …

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Modified R-GLIM Score Is a Good Prognostic Tool to Predict a Long-Term Prognosis in Poor Conditioned Elderly Patients with Aspiration Pneumonia, a Pilot Study

Yoshinori Wakita, Nobuhiro Asai, Wataru Ohashi, Naoharu Mori et autres

Background. While prognostic guidelines for pneumonia have widely allowed clinicians to treat patients, poor prognostic factors for 1- or 2-year survival times have never been mentioned to our knowledge. Patients and methods. We conducted this retrospective study to evaluate whether malnutrition according …

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Hydrogen Embrittlement Detection Technology Using Nondestructive Testing for Realizing a Hydrogen Society

Yamato Abiru, Hiroshi Nishiguchi, Masato Maekawa, T. Nagata et autres

Crack detection in high-pressure hydrogen gas components, such as pipes, is crucial for ensuring the safety and reliability of hydrogen infrastructure. This study conducts the nondestructive testing of crack propagation in steel piping under cyclic compressive loads in the presence of hydrogen …

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The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a

Masato Maekawa, Shinji Saito, Daiki Isobe, Kazumasa Takemoto et autres

Using a transgenic zebrafish line harboring a heat-inducible dominant-interference pou5f3 gene (en-pou5f3), we reported that this PouV gene is involved in isthmus development at the midbrain-hindbrain boundary (MHB), which patterns the midbrain and cerebellum. Importantly, the functions of pou5f3 reportedly differ before …

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Factors Associated with Defecation Satisfaction among Japanese Adults with Chronic Constipation

Sayuri Yamamoto, Wataru Ohashi, Yoshiharu Yamaguchi, Hiroki Igari et autres

Background: Constipation causes substantial morbidity worldwide. Methods: This survey assessed constipation-related factors in Japan using the Japanese version of the Irritable Bowel Syndrome Quality of Life (IBS-QOL-J) instrument. We also examined the relationship among laxative type, Bristol Stool Form Scale (BSFS) scores, …

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