Vincent Cassart

Impact of changing open-label drug prescription policies on consent rates in a neonatal trial: a quasinatural experiment

Kelly K. Storm, Robert B. Flint, Wes Onland, Sylvia A Obermann-Borst et autres

OBJECTIVE: To assess how restricting open-label access to an off-label drug influences consent and trial enrolment in neonatal medicine. DESIGN: Multicentre, quasinatural experiment. SETTING: Seventeen neonatal intensive care units in the Netherlands and Belgium participating in the DOXA-trial, a double-blind, randomised, placebo-controlled …

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Doxapram versus placebo in preterm newborns: a study protocol for an international double blinded multicentre randomized controlled trial (DOXA-trial)

Jarinda A. Poppe, Robert B. Flint, Anne Smits, Sten Paul Willemsen et autres

BACKGROUND: Apnoea of prematurity (AOP) is one of the most common diagnoses among preterm infants. AOP often leads to hypoxemia and bradycardia which are associated with an increased risk of death or disability. In addition to caffeine therapy and non-invasive respiratory support, …

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Doxapram versus placebo in preterm newborns: a study protocol for an international double blinded multicentre randomized controlled trial (DOXA-Trial)

Jarinda A. Poppe, Robert B. Flint, Anne Smits, Sten Paul Willemsen et autres

Abstract Background Apnoea of prematurity (AOP) is one of the most common diagnoses among preterm infants. AOP often leads to hypoxemia and bradycardia which are associated with an increased risk of death or disability. In addition to caffeine therapy and non-invasive respiratory …

nl, be, us, ca (code pays fourni par la source)

Naël e stato accompagnato

Marie Friedel, Brigitte De Terwangne, Marie Kirsch, Vincent Cassart