Petroula Arapantoni-Dadioti

Integrating molecular classification in adenoid cystic carcinoma of the head and neck: The experience from four tertiary centers in Greece

Panagiota Economopoulou, Theodoros Pantazopoulos, Danai Leventakou, Nektarios I. Koufopoulos et autres

BACKGROUND: Recently, a molecular characterization of adenoid cystic carcinoma (ACC) has been proposed, based on upregulation of c-Myc, a proto-oncogene involved in carcinogenesis, and p63, a transcription factor of the p53 gene family. The aim of this study was to evaluate c-Myc …

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61P Deep learning prediction of response to antibody-drug conjugates in patients with metastatic breast cancer using digital pathology

Suresh Jayabalan, Niki Arnogiannaki, Kyriaki Papadopoulou, Electra Sofou et autres

Antibody-drug conjugates (ADCs) have altered the therapeutic landscape of advanced breast cancer (aBC). We developed a prognostic deep learning-based model on whole-slide images (WSIs) from patients (pts) with aBC treated with ADCs.

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Nationwide Real-World Data of Microsatellite Instability and/or Mismatch Repair Deficiency in Cancer: Prevalence and Testing Patterns

Elena Fountzilas, Theofanis Papadopoulos, Eirini Papadopoulou, Cédric Gouédard et autres

Determination of microsatellite instability (MSI)/mismatch repair (MMR) status in cancer has several clinical implications. Our aim was to integrate MSI/MMR status from patients tested in Greece to assess the prevalence of MSI-high (MSI-H)/deficient MMR (dMMR) per tumor type, testing patterns over time …

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Ten-year clinical outcome, toxicity and compliance of dose-dense sequential adjuvant administration of cyclophosphamide & epirubicin followed by docetaxel in patients with early breast cancer: A hellenic cooperative oncology group observational study (HE 10/10) with concurrent investigation of significance of tumor infiltrating lymphocytes

Foteinos-Ioannis D. Dimitrakopoulos, ANNA C. GOUSSIA, Georgia-Angeliki Koliou, Katerina Dadouli et autres

Background Dose-dense sequential (dds) chemotherapy has changed the clinical outcome of patients with early breast cancer (BC). To investigate the impact of dose intensity (DI) in the adjuvant setting of BC, this observational trial (HE 10/10) was conducted assessing the long-term survival …

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79P Ten-year clinical outcome, toxicity and compliance of dose-dense sequential adjuvant administration of cyclophosphamide & epirubicin followed by docetaxel in patients with early breast cancer: An observational study with concurrent investigation of significance of TILs

F-I.D. Dimitrakopoulos, ANNA C. GOUSSIA, Georgia-Angeliki Koliou, Katerina Dadouli et autres

Dose-dense sequential (dds) chemotherapy has tremendously changed the clinical outcome of patients with early breast cancer (BC). To investigate the impact of dose intensity (DI) in the adjuvant setting of BC, this observational trial (HE 10/10) was conducted assessing the long-term survival …

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Significance of MYB and NTRK Expression in Head and Neck Adenoid Cystic Carcinoma

Theodoros Pantazopoulos, Danai Leventakou, Nektarios I. Koufopoulos, Abraham Pouliakis et autres

BACKGROUND/AIM: Adenoid cystic carcinoma (ACC) is an aggressive neoplasm even though it has low-grade histological appearance and slow growth. The aim of this study was to identify the immunohistochemical and molecular characteristics of ACC, as well as their correlation with the clinical …

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Prognostic Impact of Src, CDKN1B, and JAK2 Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab

Panagiota Economopoulou, Vassiliki Kotoula, Georgia-Angeliki Koliou, Kyriaki Papadopoulou et autres

BACKGROUND: Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T). METHODS: …

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Abstract P4-08-13: Prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in patients with early breast cancer (EBC) treated with dose-dense sequential adjuvant chemotherapy (dds-CT). An observational study (ACTRN12616001043426)

HP Kourea, Triantafyllia Κoletsa, Vassiliki Kotoula, G-A. Koliou et autres

Abstract Background - aim: Information on the prognostic role of cytotoxic CD8+ T cells in the era of modern adjuvant CT is limited. The primary objective of the present report is to assess the prognostic impact of CD8+ cells in patients with …

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Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

Amanda K. Psyrri, Konstantine T. Kalogeras, Ralph Markus Wirtz, George Kouvatseas et autres

BACKGROUND: The shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk for relapse and metastatic spread and indicate the potential value of additional treatment strategies. Osteopontin (OPN) is a matricellular protein …

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Carcinoid heart disease in an elderly female patient: the value of transthoracic echocardiography

Pavlos N. Stougiannos, George Michas, Constantinos Evdoridis, Petroula Arapantoni-Dadioti et autres

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MOESM1 of Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

Amanda K. Psyrri, Konstantine T. Kalogeras, Ralph Markus Wirtz, George Kouvatseas et autres

Additional file 1. OPN supplementary data.

MOESM1 of Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

Amanda K. Psyrri, Konstantine T. Kalogeras, Ralph Markus Wirtz, George Kouvatseas et autres

Additional file 1. OPN supplementary data.