Isabella Lemuqui Tegami

Brazilian biorepository to support genome-wide association studies of colorectal, breast, and cervical cancer

Lázaro Antônio Campanha Novaes, Rafaela Dias Oliveira, Isabella Lemuqui Tegami, Maria Fernanda Santiago Gonçalves et autres

Genome-wide association studies (GWAS) have identified numerous genetic variants associated with cancer susceptibility. However, over 90% of participants are of European ancestry, limiting the applicability to highly admixed groups such as Brazilians. To address this gap, we established a large-scale Brazilian biorepository …

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-gene signature as a prognostic and predictive tool for adjuvant chemotherapy response in non-small cell lung cancer patients: a multicentric study

Maria Fernanda Santiago Gonçalves, Aléxia Polo Siqueira, Isabella Lemuqui Tegami, Keila Cristina Miranda et autres

Fluid-specific miRNA-based signatures for lung cancer screening

Giovanna Maria Stanfoca Casagrande, Rodrigo Sampaio Chiarantano, Alexia Polo, Ana Carolina Laus et autres

Introduction: Lung cancer is the deadliest cancer worldwide. Lung cancer screening has been applied in high-risk subjects and has proven to reduce lung cancer deaths in high-income countries. Biomarkers detection in body fluids may guide more precise selection of high-risk subjects but …

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Validation of a 5-gene signature for predicting outcomes in early-stage NSCLC patients

Keila Cristina Miranda, Aléxia Polo Siqueira, Maria Fernanda Santiago Gonçalves, Isabella Lemuqui Tegami et autres

Background: Early-stage non-small cell lung cancer(NSCLC) present high rates of recurrence, even undergoing curative treatment such as surgery and/or adjuvant chemotherapy(ACT). Specific criteria lack to define a therapeutic approach that offers the maximum survival benefit for prognosis improvement. Aim: To validate a …

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Reproducibility of a 12-gene set for predicting outcome and benefit from ACT in early-stage NSCLC patients

Aléxia Polo Siqueira, Maria Fernanda Santiago Gonçalves, Isabella Lemuqui Tegami, Keila Cristina Miranda et autres

Background: Recommendation of adjuvant chemotherapy(ACT) is based on tumor size and lymph node invasion for early-stage surgically resected non-small cell lung cancer(NSCLC) patients. Specific criteria lack to define who will be benefit from ACT. Aim: To evaluate the reproducibility of a 12-gene …

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Identification of potential biomarkers for diagnosis of lung adenocarcinoma

Isabella Lemuqui Tegami, Giovanna Maria Stanfoca Casagrande, Luciane Sussuchi da Silva, Rodrigo Oliveira Cavagna et autres

Background: Lung cancer is the deadliest cancer worldwide. Therapeutic options for lung adenocarcinoma(LUAD) have dramatically increased, but late diagnosis remains a challenge. Differentially expressed genes(DEG) may be employed as biomarkers for LUAD detection. Aim: To identify potential biomarkers for diagnosis of LUAD. …

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PD.02.04 A Prognostic Value of 3 Gene Sets for Ever-Smokers With Non-small Cell Lung Cancer From Brazil

Isabella Lemuqui Tegami, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Maria Fernanda Santiago Gonçalves et autres

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PSP.03 12-Gene Expression Signature: A Potential Key for Predicting Prognosis and Benefit to ACT for Resectable NSCLC Patients

Aléxia Siqueira, Maria Fernanda Santiago Gonçalves, Isabella Lemuqui Tegami, Keila Cristina Miranda et autres

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