Fiona Maggs

A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomised controlled trials of immunomodulatory therapies

Sophie Beese, Malcolm J Price, Claire L Tomlinson, Pawana Sharma et autres

Abstract Background Type 1 diabetes is characterised by the immune-mediated destruction of pancreatic beta cells. We aimed to determine the effectiveness of immunotherapies for preserving residual beta cell function in newly diagnosed (stage 3) type 1 diabetes. Methods Searches were carried out …

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A systematic review and meta‐analysis of interventions to preserve insulin‐secreting β‐cell function in people newly diagnosed with type 1 diabetes: Results from intervention studies aimed at improving glucose control

Parth Narendran, Claire L Tomlinson, Sophie Beese, Pawana Sharma et autres

AIMS: Type 1 diabetes is characterised by the destruction of pancreatic β-cells. Significant levels of β-cells remain at diagnosis. Preserving these cells improves glucose control and protects from long-term complications. We undertook a systematic review and meta-analyses of all randomised controlled trials …

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AB0279 Incidence of diabetes and effect of etanercept and adalimumab on hba1c over 1 year: data from a randomised trial in patients with rheumatoid arthritis

Paola de Pablo, Fiona Maggs, David Carruthers, Abdul Faizal et autres

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Case Reports * 1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGF Receptor Mutations in Benign Joint Hypermobility

Puja Mehta, Sue Holder, BA Fisher, Tonia L. Vincent et autres

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth …

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Muscle disorders * 111. The impact of fatigue in patients with idiopathic inflammatory myopathy: a mixed method study

R. Campbell, Darija Hofmann, Stephani L. Hatch, Patrick Gordon et autres

Background: Fatigue is a core symptom of idiopathic inflammatory myopathies (IIM) and impacts on quality of life more than any other common symptom according to findings from our past research project.Due to the subjective nature of fatigue and the lack of evidence-based …

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A randomised efficacy and discontinuation study of etanercept versus adalimumab (RED SEA) for rheumatoid arthritis: a pragmatic, unblinded, non-inferiority study of first TNF inhibitor use: outcomes over 2 years

Paresh Jobanputra, Fiona Maggs, A. Deeming, David Carruthers et autres

OBJECTIVE: To compare adalimumab versus etanercept in patients with active rheumatoid arthritis (RA) to test the hypothesis that adalimumab was not inferior to etanercept in terms of drug continuation by a margin of 15% after 52 weeks of treatment. DESIGN: Pragmatic, randomised, …

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Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events

Paresh Jobanputra, Roshan Amarasena, Fiona Maggs, Dawn Homer et autres

BACKGROUND: Spontaneous reporting systems for adverse drug reactions (ADRs) are handicapped by under-reporting and limited detail on individual cases. We report an investigation from a local surveillance for serious adverse drug reactions associated with disease modifying anti-rheumatic drugs that was triggered by …

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A pragmatic randomised controlled trial of hydrotherapy and land exercises on overall well being and quality of life in rheumatoid arthritis

Lis Eversden, Fiona Maggs, Peter Nightingale, Paresh Jobanputra

BACKGROUND: Hydrotherapy is highly valued by people with rheumatoid arthritis yet few studies have compared the benefits of exercises in heated water against exercises on land. In particular, data on quality of life is rarely reported. This is especially important because patients …

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Monitoring and Assessing the Safety of Disease-Modifying Antirheumatic Drugs

Paresh Jobanputra, Fiona Maggs, Dawn Homer, Jessica Bevan

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SINGLE-BLIND RANDOMIZED CONTROLLED TRIAL OF AN EDUCATIONAL BOOKLET FOR PATIENTS WITH CHRONIC ARTHRITIS

Fiona Maggs, R. W. Jubb, John Kemm

Consecutive new attendees at a rheumatology clinic were randomly allocated to one of three groups. All groups received routine care, but one received no other intervention, one an educational booklet on arthritis and one the booklet plus instruction from a health professional. …

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