Claire R. W. Kaiser

Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release

Marcus Flowers, Alex D. Paulsen, Claire R. W. Kaiser, Adam B. Tuma et autres

Background/Objectives: Focused ultrasound has advantages as an external stimulus for drug delivery as it is non-invasive, has high precision and can penetrate deep into tissues. Here, we report a gold-plated alginate (ALG) hydrogel system that retains highly water-soluble small-molecule fluorescein for sharp …

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Rib detection using pitch-catch ultrasound and classification algorithms for a novel ultrasound therapy device

Claire R. W. Kaiser, Adam B. Tuma, Maryam Zebarjadi, Daniel P. Zachs et autres

BACKGROUND: Noninvasive ultrasound (US) has been used therapeutically for decades, with applications in tissue ablation, lithotripsy, and physical therapy. There is increasing evidence that low intensity US stimulation of organs can alter physiological and clinical outcomes for treatment of health disorders including …

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Single-step label-free nanowell immunoassay accurately quantifies serum stress hormones within minutes

Seyed Reza Mahmoodi, Pengfei Xie, Daniel P. Zachs, Erik J Peterson et autres

A non-faradaic label-free cortisol sensing platform is presented using a nanowell array design, in which the two probe electrodes are integrated within the nanowell structure. Rapid and low volume (≤5 μl) sensing was realized through functionalizing nanoscale volume wells with antibodies and …

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First-in-human demonstration of splenic ultrasound stimulation for non-invasively controlling inflammation

Daniel P. Zachs, Victoria E. Cotero, Catherine A. D’Agostino, Despοina Ntiloudi et autres

Abstract Hyperinflammation and uncontrolled cytokine release in infections and autoimmune diseases require therapy to reduce the innate immune response. Here, we present first in-human data showing reduction in pro-inflammatory cytokine release with ultrasound stimulation of the spleen in healthy subjects and in …

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Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor–Transgenic Mouse Model of Rheumatoid Arthritis

Richard D. Bell, Emily Wu, Christopher A. Rudmann, M.N. Forney et autres

OBJECTIVE: To examine and quantify the sexual dimorphism in pathologic features manifested in the musculoskeletal and cardiopulmonary systems and incidence of mortality in the tumor necrosis factor-transgenic (TNF-Tg; Tg3647 strain) mouse model of inflammatory erosive arthritis. METHODS: Kaplan-Meier survival estimates were determined …

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Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis

Daniel P. Zachs, Sarah J. Offutt, Yohan Kim, Jerel Mueller et autres

Targeted noninvasive control of the nervous system and end-organs may enable safer and more effective treatment of multiple diseases compared to invasive devices or systemic medications. One target is the cholinergic anti-inflammatory pathway that consists of the vagus nerve to spleen circuit, …

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Enhanced Microgas Chromatography Using Correlation Techniques for Continuous Indoor Pollutant Detection

William César, F. Flourens, Claire R. W. Kaiser, Christophe Sutour et autres

We present for the first time a proof-of-concept system implementing the stochastic injection techniques within a silicon-based microgas chromatograph (μGC) which differs from standard laboratory chromatographs by its small size, shorter column and corresponding elution times, and potential low cost when batch …

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High-sensitivity micro-gas chromatography using stochastic injection techniques

William César, F. Flourens, Claire R. W. Kaiser, Christophe Sutour et autres

In this paper we report an improvement by an order of magnitude of the detection limit of micro gas chromatography systems through the use of m-sequence stochastic injection patterns. Using a sequence length of 127 and using a concentration level of 10 …

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Untersuchung der Zusammensetzung von Gallensteinen mittels Infrarotspektroskopie im Hinblick auf eine computertomographische Charakterisierung in vivo

Claire R. W. Kaiser, K. Karatzidou, J.D. Kruse-Jarres

Article Untersuchung der Zusammensetzung von Gallensteinen mittels Infrarotspektroskopie im Hinblick auf eine computertomographische Charakterisierung in vivo was published on January 1, 1988 in the journal Biomedical Engineering / Biomedizinische Technik (volume 33, issue s2).

Laboratory test system to measure microbial respiration rate

Manfred van Afferden, Anne M. Hansen, Claire R. W. Kaiser, N. Chapelain

This study reports a sensible, accurate and economic method for continuous measuring microbial respiration. The measuring principle is an open system, with a continuous air-flow through. Evolved CO2 is absorbed and precipitated as carbonate by a Ba(OH)2 solution, causing a stoichiometrical decrease …