Henk‐Jan Ramaker

The Physician Global Assessment as a Proxy for Photoaging: Validation in an Observational Real‐World Cohort Using SCINEXA as the Reference Standard

Ewout Baerveldt, Eric van Sprang, Henk‐Jan Ramaker, Robert T. Aeneae Venema et autres

ABSTRACT Background Photoaging is a chronic skin condition caused by cumulative ultraviolet exposure superimposed on intrinsic aging. Although the SCore of INtrinsic and EXtrinsic skin Aging (SCINEXA) is a validated multidimensional instrument for assessing photoaging, the Physician Global Assessment (PGA) is a …

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Rapid On-Site NIR Spectroscopic Characterization of CWA Liquids Using a Novel 3D-Printed Glass Cell

Jelle C. de Koning, Marcel J. van der Schans, Lai Fun Chau, Tom Venema et autres

After an incident with suspected use of chemical warfare agents (CWAs) has occurred, fast and reliable detection and identification are pivotal to take the right actions and limit the afflicted damage. Current available methodologies face practical, selectivity, or sensitivity limitations. Near-infrared spectroscopy …

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Portable near-infrared detection to replace color tests in an analytical scheme for forensic drug identification

Annique van Beek, Laura I. Stuyver, Henk‐Jan Ramaker, Emile M. Mes et autres

In the ever-changing drug market the popularity and availability of substances is dynamic. In the Netherlands, ketamine and various cathinones have recently seen increased prevalence. It is crucial for law enforcement to quickly obtain an initial indication of the identity of a …

Rapid and On-Scene Chemical Identification of Intact Explosives with Portable Near-Infrared Spectroscopy and Multivariate Data Analysis

Irene M. van Damme, Pol Mestres-Fitó, Henk‐Jan Ramaker, Annemieke Hulsbergen et autres

There is an ongoing forensic and security need for rapid, on-scene, easy-to-use, non-invasive chemical identification of intact energetic materials at pre-explosion crime scenes. Recent technological advances in instrument miniaturization, wireless transfer and cloud storage of digital data, and multivariate data analysis have …

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The influence of water of crystallization in NIR-based MDMA·HCl detection

Ruben F. Kranenburg, Henk‐Jan Ramaker, Yannick Weesepoel, Peter W.F. Arisz et autres

The large numbers of 3,4-methylenedioxy-N-methylamphetamine (MDMA) formulations encountered by the police and border security necessitates the need for safe, rapid and reliable tests to be performed on-site. Near-infrared (NIR) spectroscopy is a promising technique for on-scene illicit-drug detection because of its rapid …

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Portable near infrared spectroscopy for the isomeric differentiation of new psychoactive substances

Ruben F. Kranenburg, Henk‐Jan Ramaker, Arian C. van Asten

Rapid and efficient identification of the precise isomeric form of new psychoactive substances (NPS) by forensic casework laboratories is a relevant challenge in the forensic field. Differences in legal status occur for ring-isomeric species of the same class, thus leading to different …

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On‐site forensic analysis of colored seized materials: Detection of brown heroin and MDMA‐tablets by a portable NIR spectrometer

Ruben F. Kranenburg, Henk‐Jan Ramaker, Arian C. van Asten

The increasing workload for forensic laboratories and the expanding complexity of the drug market necessitates efficient approaches to detect drugs of abuse. Identification directly at the scene of crime enables investigative forces to make rapid decisions. Additionally, on-site identification of the material …

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A calibration friendly approach to identify drugs of abuse mixtures with a portable near‐infrared analyzer

Ruben F. Kranenburg, Henk‐Jan Ramaker, Sharon Sap, Arian C. van Asten

Both the increasing number and diversity of illicit-drug seizures complicate forensic drug identification. Traditionally, colorimetric tests are performed on-site, followed by transport to a laboratory for confirmatory analysis. Higher caseloads increase laboratory workload and associated transport and chain-of-evidence assurance performed by police …

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Pocket-size near-infrared spectrometer for narcotic materials identification

Christopher G. Pederson, Donald M. Friedrich, Chang Hsiung, Marc von Gunten et autres

While significant progress has been made towards the miniaturization of Raman, mid-infrared (IR), and near-infrared (NIR) spectrometers for homeland security and law enforcement applications, there remains continued interest in pushing the technology envelope for smaller, lower cost, and easier to use analyzers. …

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Manufacturing Vaccines: An Illustration of Using PAT Tools for Controlling the Cultivation of Bordetella pertussis

Eric N.M. van Sprang, Mathieu Streefland, Henk‐Jan Ramaker, Leo A. van der Pol et autres

An illustration of the operational consistency of the upstream part of a biopharmaceutical process is given. For this purpose four batch cultivations of Bordetella pertussis have been executed under identical conditions. The batches have been monitored by means of two fundamentally different …

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Performance assessment and improvement of control charts for statistical batch process monitoring

Henk‐Jan Ramaker, Eric N.M. van Sprang, Johan A. Westerhuis, Stephen P. Gurden et autres

This paper describes the concepts of statistical batch process monitoring and the associated problems. It starts with an introduction to process monitoring in general which is then extended to batch process monitoring. The performance of control charts for batch process monitoring is …

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Single channel event (SCE) for managing sensor failures in MSPC

Henk‐Jan Ramaker, Eric N.M. van Sprang, Johan A. Westerhuis, Age K. Smilde

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