Pan Zheng

Short-chain fatty acids alleviate acute pancreatitis by targeting IL-17A to inhibit inflammation and restore intestinal barrier function

Xueyang Li, Nianshuang Li, Yaoyu Zou, Pan Zheng et autres

BACKGROUND & AIMS: Acute pancreatitis (AP) is a life-threatening inflammatory disease with a rising incidence in which intestinal barrier dysfunction and bacterial translocation contribute to severe disease progression. Short-chain fatty acids (SCFAs), key microbial metabolites, have been linked to intestinal health, however, …

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Targeting the TNFα/TNFR1 axis alleviates the experimental acute pancreatitis

Yin Zhu, Nianshuang Li, Xiaoli Xi, Pan Zheng et autres

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Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori

Nianshuang Li, Sihai Chen, Xinbo Xu, Huan Wang et autres

Graphical summary of cellular heterogeneity and microenvironment along the consecutive gastric carcinogenesis associated with H. pylori. (A) Cellular heterogeneity along the histological cascade of gastric carcinogenesis with or without H. pylori infection. (B) The DEGs between H. pylori −positive and −negative cell …

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Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori

Nianshuang Li, Xinbo Xu, Huan Wang, Pan Zheng et autres

Abstract Background Helicobacter pylori (H. pylori) infection is a key initiating factor in the Correa cascade of gastric carcinogenesis, but the comprehensive understanding of the pathogenic mechanisms underlying H. pylori -induced gastric cancer (GC) remains elusive. Here, we generated a single-cell atlas …

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YAP and β-catenin cooperate to drive H. pylori -induced gastric tumorigenesis

Nianshuang Li, Xinbo Xu, Yuan Zhan, Fei Xiao et autres

H. pylori infection is the strongest known risk factor for gastric carcinoma. The activation of the yes-associated protein 1 (YAP) and β-catenin pathways has been associated with multiple tumor types. In this study, we investigated the crosstalk between the YAP and β-catenin …

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Nomogram for the Prediction of 30-Day Readmission in Acute Pancreatitis

Ling Ding, Pan Zheng, Xue-Yang Li, Huifang Xiong et autres

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