Amin Iranpanah

Synthesis and Evaluation of the Effects of Nanoparticles of Atorvastatin and Atorvastatin on Cuprizone-Induced Demyelination: Modulation of the Nrf2/NF-kB Signaling Pathway

Samira Shirooie, Niloofar Heidarizade, Tayebeh Noori, Antoni Sureda et autres

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by damage to the myelin sheath and, over time, by progressive neurological disability. Statins have attracted attention in MS research owing to their anti-inflammatory and neuroprotective …

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Fraxinus excelsior L. Hydromethanolic Extract Modulates Rheumatoid Arthritis Induced by Complete Freund’s Adjuvant in Rats Emphasizing Inflammatory and Antioxidant Pathways

Shirin Asar, Mohammad Mehdi Gravandi, Hosna Khazaei, Sajad Fakhri et autres

Background: Rheumatoid arthritis (RA) is a persistent inflammatory condition characterized by an imbalance in oxidative stress and chronic inflammation of joint tissues. Objectives: Fraxinus excelsior L., commonly known as ash, has demonstrated anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties. The present study aims …

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Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar

Leila Almasi, Elham Arkan, Mohammad Hosein Farzaei, Amin Iranpanah et autres

Background Growing reports are dedicated to providing novel agents for wound healing with fewer adverse effects and higher efficacy. The efficacy of nanofibers composed of polyvinyl alcohol (PVA)/polyethylene oxide (PEO)/chitosan (CS) in promoting wound healing can be attributed to their ability to …

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Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

Ghobad Mohammadi, Mosayyeb Safari, Amin Iranpanah, Mohammad Hosein Farzaei et autres

Background A growing body of research is dedicated to developing new therapeutic agents for wound healing with fewer adverse effects. One of the proceedings being taken today in wound healing research is to identify promising biological materials that not only heal wounds …

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Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K /Akt/ mTOR signaling pathway

Amin Iranpanah, Mohammad Bagher Majnooni, Hossein Biganeh, Roshanak Amirian et autres

Recently, malignant neoplasms have growingly caused human morbidity and mortality. Head and neck cancer (HNC) constitutes a substantial group of malignancies occurring in various anatomical regions of the head and neck, including lips, mouth, throat, larynx, nose, sinuses, oropharynx, hypopharynx, nasopharynx, and …

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Protective effect of a hydromethanolic extract from Fraxinus excelsior L. bark against a rat model of aluminum chloride-induced Alzheimer's disease: Relevance to its anti-inflammatory and antioxidant effects

Amin Iranpanah, Sajad Fakhri, Gholamreza Bahrami, Mohammad Bagher Majnooni et autres

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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Tara Farhadi et autres

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Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: A systematic and mechanistic approach for neurodegeneration

Mohammad Mehdi Gravandi, Sadaf Abdian, Maedeh Tahvilian, Amin Iranpanah et autres

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The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso et autres

As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. Recent studies have indicated that apoptosis, inflammation, and oxidative stress …

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Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways

Mohammad Bagher Majnooni, Sajad Fakhri, Gholamreza Bahrami, Kamran Mansouri et autres

Saponins are one of the broadest classes of high-molecular-weight natural compounds, consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing sugars attached to the sapogenin structure. Saponins are found in more than 100 plant families …

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Gentamycin Rationally Repositioned to Inhibit miR-34a Ameliorates Oxidative Injury to PC12 Cells

Zhila Izadi, Ebrahim Barzegari, Amin Iranpanah, Soraya Sajadimajd et autres

High Resolution Image Download MS PowerPoint Slide Ischemic stroke accompanies oxidative stress and cell death in the cerebral tissue. The microRNA miR-34a plays a pivotal role in this molecular pathology. This study presents the rational repositioning of aminoglycosidic antibiotics as miR-34a antagonists …

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A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

Niusha Esmaealzadeh, Amin Iranpanah, Jerome J. Sarris, Roja Rahimi

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