Accès ouvert
2026
article
OpenAlex
George W. Kasule, Joachim Nsubuga, René Lutter, Derrick Semugenze et autres
Introduction Traditional sputum-based diagnostics often demonstrate sub-optimal diagnostic performance in people living with HIV (PWH) and children presenting with paucibacillary tuberculosis (TB). This study evaluated the diagnostic accuracy of circulating kynurenine-pathway metabolites against an authentic symptomatic control cohort in Uganda. Methods Tryptophan, …
es, Ouganda, nl, Mozambique
(code pays fourni par la source)
Accès ouvert
2026
review
OpenAlex
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala et autres
BACKGROUND: Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, and treatment failure contributes to ongoing transmission, drug resistance, and poor clinical outcomes. Artificial intelligence (AI) and machine learning (ML) approaches have attracted growing interest in predicting TB treatment outcomes, …
Ouganda, nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Beston Hamasur, Anna O. Okunola, James Sserubiri, Welile V Nwamba et autres
BACKGROUND: Non-sputum-based tuberculosis tests are a global priority because sputum-dependent diagnostics systematically miss populations at highest risk of disease, including people living with HIV. We evaluated the diagnostic accuracy of a next-generation urine lipoarabinomannan assay. METHODS: In this two-centre diagnostic accuracy study, …
se, Afrique du Sud, Ouganda, fi, es
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Kevin Komakech, Ivan Sserwadda, James Sserubiri, Moses Joloba et autres
ABSTRACT Global tuberculosis (TB) incidence is slowly decreasing, partly because undiagnosed TB continues to fuel transmission. Point-of-care TB triage tests (TTTs) performed near a patient or at the site of patient care may help bridge this gap, but head-to-head comparisons of different …
nl, Ouganda, Maroc, Afrique du Sud, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Lydia Nakiyingi, Bernard Kikaire, Olive Mbabazi, Rose Nabatanzi et autres
Background Diagnosis of pulmonary tuberculosis (PTB) among people living with HIV (PLHIV) remains challenging, particularly in high TB/HIV burden settings. We evaluated serum biomarkers associated with active PTB and their relationship with TB-related clinical characteristics among hospitalized PLHIV in Uganda. Methods We …
Ouganda
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Emmanuel Nassinghe, Denis Musinguzi, Mercy Takuwa, Rogers Kamulegeya et autres
Abstract Tuberculosis (TB) is prevalent in Uganda and overlaps with a high rate of HIV/TB coinfection. While nearly all hospital-based TB cases in Kampala, the capital of Uganda, show clear TB symptoms, 30% or more of undiagnosed TB cases found through active …
Ouganda, us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala et autres
Abstract Background Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, and treatment failure contributes to ongoing transmission, drug resistance, and poor clinical outcomes. Artificial intelligence and machine learning approaches have attracted growing interest for predicting tuberculosis treatment outcomes, but …
Ouganda, nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jean de Dieu Iragena, Esther Uwimaana, Derrick Semugenze, Kevin Komakech et autres
Background: The World Health Organization (WHO) has endorsed a range of diagnostic tuberculosis (TB) over the years. A little is documented about the uptake in the WHO African Region (WHO/FR). Objective: We assessed the uptake of the endorsed diagnostic technologies for tuberculosis …
Ouganda, nl, be
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Anne A. Kapaata, Edward Nelson Kankaka, Juliet Asio, Alisen Ayitewala et autres
OBJECTIVES: To determine the prevalence and patterns of HIV drug resistance mutations among pregnant and breastfeeding women in Uganda following the rollout of dolutegravir, characterize circulating HIV-1 subtypes and their association with resistance, and identify factors associated with vertical HIV transmission. MATERIALS …
Ouganda, us, my
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jean de Dieu Iragena, Achilles Katamba, Dissou Affolabi, Moses Lutaakome Joloba et autres
Tuberculosis remains a leading infectious disease killer in the World Health Organization African Region, with 2.5 million cases and 404,000 deaths in 2023, including 112,000 people with HIV. There is slow progress with only 42% of the 75% targeted reduction in death …
Ouganda, Bénin
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lucía Carratalá-Castro, Shilzia Munguambe, Alexander W. Kay, Willy Ssengooba et autres
New diagnostic tests and alternative samples to diagnose tuberculosis in children are needed to tackle the diagnostic gap of pediatric tuberculosis. The Determine TB LAM Ag test in urine demonstrated sensitivity of 15.9% and specificity of 90.6%. Collecting the urine in adhesive …
es, Mozambique, us, Ouganda, gb, Eswatini, nl, de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Devendra Singh Parihar, Joshua Jansen van Vüren, Thomas Niesler, Grant Theron et autres
ABSTRACT We consider the application of machine learning to the classification of tuberculosis (TB) based on clinical and demographic data. Such data is routinely collected from people who present with cough at community-level care centres. Therefore, such automatic classification could identify people …
Afrique du Sud, nl, de, Ouganda
(code pays fourni par la source)