Hua‐Li Zuo

Patent analysis of mRNA therapy using deep learning

Yuanqi Cai, Xuejing Zhang, Xiaoming Zhang, Jianxiong Ren et autres

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Ligusticum chuanxiong Hort. Targets hsa-miR-10a-5p to Potentially Induce Apoptosis and Modulate Lipid Metabolism in Glioblastoma: A Natural-Product-Based Therapeutic Strategy

Xiaoxuan Cai, Hua‐Li Zuo, Jing Li, Hsi‐Yuan Huang et autres

Background/Objectives: Glioblastoma (GBM), the most aggressive primary malignant brain tumor, has a dismal prognosis and limited treatment options. The dried rhizome of Ligusticum chuanxiong Hort. (Chuanxiong, CX) is a traditional Chinese medicinal herb frequently prescribed in formulas intended to invigorate blood circulation. …

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Integrative Framework for Functional analysis of multiple Traditional Chinese Medicines based on transcriptome-driven systems biology and supervised learning strategy

Yun Tang, Chia‐Ru Chung, Yang-Chi-Dung Lin, Hua‐Li Zuo et autres

Traditional Chinese Medicines (TCMs) contain a wide variety of ingredients and are rich in bioactive chemical sources. However, their complex and unknown effects on the human body prove a challenge in TCM research. Multiple genes are involved in a biological system and …

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Dietary Omega-3 PUFAs in Metabolic Disease Research: A Decade of Omics-Enabled Insights (2014–2024)

Jing Li, Yang-Chi-Dung Lin, Hua‐Li Zuo, Hsi‐Yuan Huang et autres

Background/Objectives: The rising global prevalence of metabolic diseases (e.g., obesity, type 2 diabetes mellitus) underscores the need for effective interventions. Omega-3 polyunsaturated fatty acids (PUFAs) exhibit therapeutic potential, yet their molecular mechanisms remain unclear. This systematic review synthesizes a decade (2014–2024) of …

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RegRNA 3.0: expanding regulatory RNA analysis with new features for motif, interaction, and annotation

Yixian Huang, Zhiyong Zhang, Zhengkai Zou, Lingquan Zhang et autres

Functional RNA molecules are crucial for biological processes from gene regulation to protein synthesis, and analyzing functional motifs and elements is essential for understanding RNA regulation. Building on RegRNA 1.0 and 2.0, we present RegRNA 3.0, a sophisticated meta-workflow that integrates 26 …

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A comprehensive review of small molecules, targets, and pathways in ulcerative colitis treatment

Xiaoxuan Cai, Yi-Han Huang, Yang-Chi-Dung Lin, Hsi‐Yuan Huang et autres

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Mechanistic Insights into Pigmented Rice Bran in Mitigating UV-Induced Oxidative Stress, Inflammation, and Pigmentation

Hua‐Li Zuo, Yue Liu, Hsi‐Yuan Huang, Shangfu Li et autres

As an agri-food by-product, the rice bran of pigmented rice, encompassing varieties such as red, black, and purple rice, has garnered increasing attention due to its richness in terms of bioactive compounds. Being mainly composed of the pericarp, aleuron, seed coat, and …

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Unveiling Novel miRNA–mRNA Interactions and Their Prognostic Roles in Triple-Negative Breast Cancer: Insights into miR-210, miR-183, miR-21, and miR-181b

Jiatong Xu, Xiaoxuan Cai, Junyang Huang, Hsi‐Yuan Huang et autres

Triple-negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive progression and limited treatment options, making early diagnosis and prognosis critical. MicroRNAs (miRNAs) are crucial post-transcriptional regulators that influence gene expression. In this study, we unveil novel miRNA-mRNA interactions …

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Identifying Baicalein as a Key Bioactive Compound in XueBiJing Targeting KEAP1: Implications for Antioxidant Effects

Ting-Xuan Lin, Xiaoxuan Cai, Yibing Wang, Jiatong Xu et autres

Background: XueBiJing injection (XBJ) is renowned for its multi-target pharmacological effects, including immunomodulatory, antithrombotic, and antioxidant activities, offering potential therapeutic benefits for patients with severe infections such as sepsis and Coronavirus disease 2019 (COVID-19). Despite its clinical effectiveness, the molecular targets and …

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Gene Targeting on Point: Targeted Delivery of Tumor Suppressor Gene CHRDL‐1 via Peptide/FA‐Modified Layered Double Hydroxides Partner With JPH203 for Effective Hepatocellular Carcinoma Inhibition

Zhouyi Sun, Yang Liu, Tangye Zeng, Hua‐Li Zuo et autres

Abstract The incidence of hepatocellular carcinoma (HCC) is increasing worldwide annually. However, traditional treatments like surgery, targeted therapy, and immunotherapy have limited efficacy, often accompanied by adverse reactions or drug resistance. Precision therapy via tumor‐specific gene therapy and targeted delivery would potentially …

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Cynomorium songaricum: UHPLC/ESI-LTQ-Orbitrap-MS analysis and mechanistic study on insulin sensitivity of a flavonoid-enriched fraction

Zhihao Liu, Qixiang Shang, Hua‐Li Zuo, Haimeng Li et autres

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Intrarelationships between suboptimal health status and anxiety symptoms: A network analysis

Yangyu Liu, Pu Ge, Xiaoming Zhang, Yunchou Wu et autres

BACKGROUND: Suboptimal health status is a global public health concern of worldwide academic interest, which is an intermediate health status between health and illness. The purpose of the survey is to investigate the relationship between anxiety statuses and suboptimal health status and …

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