Pilkington Gj

The role of growth factors in the malignant and invasive progression of intrinsic brain tumours.

Finn Pe, Rolf Bjerkvig, Pilkington Gj

Although growth factors are acknowledged for their mitogenic activity, a number of other functions are fulfilled by such peptides. These include control of motile and invasive behaviour, angiogenesis and phenotype. Various growth factors including epidermal growth factor, fibroblast growth factor, platelet derived …

The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure.

Pilkington Gj

Brain tumours fall into 3 major categories: a) secondary tumours which have originated in distant parts of the body, b) meningiomas, which generally grow on, rather than in, the substance of the brain and c) intrinsic tumours which are generally composed of …

Establishment and characterization of two paediatric brain tumour cell lines in vitro.

Rooprai Hk, Abderrahim Merzak, Peter L. Bullock, Pilkington Gj

Well-characterised, established cell lines derived from paediatric brain tumours are rare. The paucity of medulloblastoma cell lines may reflect--at least in part--the differences in cell adhesion molecule expression between the cells of primitive neoplasms of childhood and their better-differentiated adult counterpart neoplasms. …

pl (code pays fourni par la source)

The influence of sequential, in vitro passage on secretion of matrix metalloproteinases by human brain tumour cells.

Martina Rossi, Rooprai Hk, Maidment Sl, Rucklidge Gj et autres

Matrix metalloproteinases (MMP) are a family of zinc-dependent enzymes which degrade various components of the extracellular matrix (ECM) and play an important role in facilitating tumour cell invasion of the normal brain. The family includes the gelatinases, stromelysins and collagenases. Preliminary studies …

gb (code pays fourni par la source)

The biology, pathogenesis and spread of malignant glioma.

Pilkington Gj