Clayton Ryan Boldt

Abstract 438: Development of an autoantibody panel that reflects disease pathogenesis in ovarian cancer

Makoto Kobayashi, Clayton Ryan Boldt, Wei‐Lei Yang, Clemente Aguilar-Bonavides et autres

Abstract Introduction The serous subtype of ovarian cancer is responsible for most ovarian cancer deaths. When patients are diagnosed with early stage disease localized to the ovary or pelvis, current therapies can achieve survival rates up to 75-90%. However, approximately 70% of …

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Crossbred Bos indicus steer temperament as yearlings and whole genome association of steer temperament as yearlings and calf temperament post-weaning12

David Greg Riley, Clare A. Gill, Clayton Ryan Boldt, Rena Rebecca Funkhouser et autres

cattle often have the reputation for a poor or dangerous temperament. Identification of genomic regions that associate with temperament of such cattle may be useful for genetic improvement strategies. The objectives of this study were to evaluate subjective temperament scores (1 to …

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Abstract AS12: Integrating genomics, transcriptomics, and proteomics for the discovery of novel biomarkers to complement CA125 in ovarian cancer early detection

Clayton Ryan Boldt, Archana R. Simmons, Hong Wang, Keith Baggerly et autres

Abstract Recent work suggests that a 2-stage strategy incorporating serial measurements of the glycoprotein CA125 in patient serum and the Risk of Ovarian Cancer Algorithm (ROCA), followed by transvaginal ultrasound for women with high-risk scores, may have utility as a screening practice …

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An Autoimmune Response Signature Associated with the Development of Triple-Negative Breast Cancer Reflects Disease Pathogenesis

Hiroyuki Katayama, Clayton Ryan Boldt, Jon J. Ladd, Melissa Martinez Johnson et autres

The repertoire of antigens associated with the development of an autoimmune response in breast cancer has relevance to detection and treatment strategies. We have investigated the occurrence of autoantibodies associated with the development of triple-negative breast cancer (TNBC) in the before diagnosis …

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Identification of Developmental Signaling Pathways with a Novel Role in Regulating Zebrafish Primordial Germ Cell Migration

Clayton Ryan Boldt

The file named BOLDT-DISSERTATION-2013.pdf is the primary dissertation file. Four (4) supplemental videos are also provided (in Audio Video Interleaved format).

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Christine G. Elsik, Ross L. Tellam, Kim C. Worley, Richard A. Gibbs et autres

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are …

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A Study of Cattle Disposition: Exploring QTL Associated with Temperament

Clayton Ryan Boldt

In any production setting, cattle disposition (temperament) has a great impact on handling and performance. Thus, behavior can be economically important, yielding the rationale for study. Wegenhoft (2005) previously identified several quantitative trait loci (QTL) for disposition, including a partially paternally imprinted …