Manish Kumar Jain

Shikonin inhibits Vascular Smooth Muscle Cell Phenotypic Modulation and attenuates Neointimal Hyperplasia

Ankan Sarkar, Sakeel Ahmed, Monika Singh, Shyam Sunder Sharma et autres

Purpose: Enhanced glycolytic activity drives vascular smooth muscle cell proliferation and migration. Pyruvate kinase M2, a key glycolytic enzyme, modulates cancer cell proliferation. Shikonin, an inhibitor of pyruvate kinase M2, exerts anti-proliferative effects on cancer cells; still, its involvement in vascular smooth …

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EVALUATION OF SERUM COPPER, ZINC, IRON AND MAGNESIUM LEVELS IN PATIENTS WITH ORAL SUBMUCOUS FIBROSIS: A HOSPITAL-BASED COMPARATIVE CASE CONTROL STUDY

Manish Kumar Jain, Abhishek Singhvi, Dr. Gurdeep Singh, Dr. Neeraj Saraswat et autres

Background: Oral Submucous Fibrosis (OSMF) is a long-lasting and progressive disorder that can become cancerous. It is mainly linked to chewing areca nut and smokeless tobacco. The condition causes the tissues in the mouth to become stiff, which leads to limited mouth …

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A Comprehensive Review On Role Of Linear Algebra In Artificial Intelligence And Various Engineering Applications

Manish Kumar Jain, Dharmendra Singh Sengar, Abhendra Pratap Singh, Yash Kumar et autres

AI is growing much faster in every field including engineering and linear algebra has provided a strong base for it. Linear Algebra is a core branch of mathematics which is used in mostly all engineering fields. This review paper carries out its …

A Comprehensive Review On Role Of Linear Algebra In Artificial Intelligence And Various Engineering Applications

Manish Kumar Jain, Dharmendra Singh Sengar, Abhendra Pratap Singh, Yash Kumar et autres

AI is growing much faster in every field including engineering and linear algebra has provided a strong base for it. Linear Algebra is a core branch of mathematics which is used in mostly all engineering fields. This review paper carries out its …

Association of long COVID with health-related quality-of-life outcomes

Malini M. Gandhi, Carlee Moser, Judith S. Currier, Justin Ritz et autres

The association of long COVID with health-related quality-of-life (HrQOL) has not been well-characterized. Participants who received blinded placebo in the ACTIV-2/A5401 outpatient COVID-19 treatment trial were included in an analysis of the association of long COVID with HrQOL (both pre-specified exploratory trial …

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Copper‐Based Crystalline‐Metallic Glass Composite Thin Films: A Novel Material with Enhanced Strength and Thermally Stable Nanotwins

Chunhua Tian, Amit Sharma, Krzysztof Wieczerzak, Alexander Groetsch et autres

ABSTRACT Nanotwinned crystalline‐glass composite thin films achieve enhanced performance by effectively utilizing the complementary properties of both phases. Combinatorial sputtering emerges as a powerful tool to discover new materials with targeted properties. In this study, by co‐sputtering Cu, Ti, and Re, Cu‐rich …

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Targeting PDK4 attenuates neointimal hyperplasia and regulates VSMC phenotypic switching, apoptosis, and autophagy

Ankan Kumar Sarkar, Sakeel Ahmed, Monika Singh, Zahid Bashir Zargar et autres

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230. A Novel SARS-CoV-2 mRNA Virus-Like Particle Vaccine is Highly Potent and Well Tolerated in Adults in a Phase I Randomized Clinical Trial

Tope Oyedele, Rachel Park, Kelly Morales, Manish Kumar Jain et autres

Abstract Background There is a need for coronavirus disease 2019 (COVID-19) vaccines with improved potency and durability, lower reactogenicity, and broader coverage against emerging SARS-CoV-2 variants. This ongoing, Phase I, open-label, randomized, active-controlled study examined the safety and immunogenicity of two novel …

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Design, Synthesis, Biological Evaluation, and In Silico Study of N ‐(Pyrazin‐2‐yl)Alkyl/Aryl Amide Derivatives as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa

Anand Mohan Yadav, Isha Mahindru, Namita Srivastava, Rajnish Kumar et autres

This research develops novel quorum sensing inhibitors (QSIs) that function as anti-biofilm agents and reduce quorum sensing (QS) to effectively combat Pseudomonas aeruginosa. N-(Pyrazin-2-yl)alkyl/aryl amide derivatives (3a-k) and (5a-j) were designed and synthesized in this study. Further, QS inhibition activity of N-(pyrazin-2-yl)alkyl/aryl …

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Real-World Analysis of Initial Clinical Response and Future Outcomes Among Patients with Rheumatoid Arthritis Initiating and Remaining on a First-Line Tumor Necrosis Factor Inhibitor in the United States

Christina Charles‐Schoeman, Patrick Zueger, Erin L. McDearmon-Blondell, Siran Fang et autres

This study aimed to evaluate a subsequent treatment response among patients with rheumatoid arthritis (RA) who initiated and remained on a first-line tumor necrosis factor inhibitor (TNFi) after achieving or not achieving an initial response. This real-world, retrospective cohort study included patients …

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Interim analysis of promise, a clinical study combining the BET inhibitor OPN-2853 with ruxolitinib in patients with advanced myelofibrosis experiencing an inadequate response to ruxolitinib

Adam J. Mead, Bethan Psaila, Rebecca H. Boucher, Jiayi Wang et autres

Abstract Background Myelofibrosis (MF) a myeloproliferative neoplasm is characterised by progressive splenomegaly, cytopenia, debilitating symptoms, and leukemic progression. MF patients (pts) classified as Dynamic International Prognostic Scoring System (DIPSS) High or Intermediate-2 (Int-2) risk have median overall survival of 2-4 years (yrs). …

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Ulnar Artery Perforator Propeller Flap: A Novel Approach for Donor Site Closure in Radial Forearm Free Flap Reconstruction

Manish Kumar Jain, Saurabh K. Garg†

Correspondence: Manish Jain (E-mail: drmanishjainms@gmail.com)

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