Vincenzo Brancaleone

Expression of Concern: Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate

Fiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, A. Bertolino et autres

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Let's consider sex contextualism within sex-aware preclinical pharmacological research

Flavia Franconi, Vincenzo Brancaleone, Ilaria Campesi, Maria Grazia Cattaneo et autres

It is now well established that consideration of sex and gender is essential to deliver effective healthcare and preventive strategies for all individuals, as well as to reduce health disparities. A sex-based perspective is indispensable in the context of drug research. This …

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Harnessing Moringa oleifera Lam's Isothiocyanates for Targeted H 2 S Delivery: A Systematic Review of the Literature

Maria Ponticelli, Rosangela Montanaro, Valentina Vellecco, Eugenia Piragine et autres

ABSTRACT The gasotransmitter hydrogen sulfide (H 2 S) and its natural donor isothiocyanates have been suggested by emerging evidence to play a significant role in the therapeutic management of several conditions like metabolic syndrome, neurodegeneration, inflammation, and so forth. In particular, isothiocyanates …

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Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1

Martina Smimmo, V. Casale, D D'Andrea, I Bello et autres

S pathway in maintaining healthy SKM function.

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Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation

Martina Smimmo, V. Casale, Gian Marco Casillo, Emma Mitidieri et autres

Here, by using in vitro and ex vivo approaches, we elucidate the impairment of the hydrogen sulfide (H2S) pathway in vascular complications associated with metabolic syndrome (MetS). In the in vitro model simulating hyperlipidemic/hyperglycemic conditions, we observe significant hallmarks of endothelial dysfunction, …

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Regulatory TR3-56 Cells in the Complex Panorama of Immune Activation and Regulation

Flavia Carriero, Valentina Rubino, Stefania Leone, Rosangela Montanaro et autres

The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms …

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Erucin Exerts Cardioprotective Effects on Ischemia/Reperfusion Injury through the Modulation of mitoKATP Channels

Lorenzo Flori, Rosangela Montanaro, Eleonora Pagnotta, Luisa Ugolini et autres

Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H2S), an endogenous pleiotropic gasotransmitter responsible for anti-ischemic cardioprotective effects also through the involvement of mitoK channels. Erucin (ERU) is …

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Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G‐Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease

Silvia Marchianò, Michele Biagioli, Martina Bordoni, Elva Morretta et autres

Background Patients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile acid–activated receptors exploited in the treatment of nonalcoholic fatty liver disease: whether dual GPBAR1/FXR agonists synergize with statins in the …

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Biphasic inflammatory response induced by intra-plantar injection of L-cysteine: Role of CBS-derived H2S and S1P/NO signaling

Valentina Vellecco, Erika Esposito, Chiara Indolfi, Anella Saviano et autres

This study investigates the inflammatory response to intra-plantar injection of L-cysteine in a murine model. L-cysteine induces a two-phase response: an early phase lasting 6 h and a late phase peaking at 24 h and declining by 192 h. The early phase …

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Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia/reperfusion injury

Lara Testai, Rosangela Montanaro, L. Flori, Eleonora Pagnotta et autres

Hydrogen sulfide (H2S) is a gasotransmitter deeply involved in cardiovascular homeostasis and implicated in the myocardial protection against ischemia/reperfusion. The post-translational persulfidation of cysteine residues has been identified as the mechanism through which H2S regulates a plethora of biological targets. Erucin (ERU) …

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Activity Methods for Cardiovascular System Diseases

Rosangela Montanaro, Emma Mitidieri, Roberta d’ Emmanuele di Villa Bianca, Vincenzo Brancaleone

This chapter provides a collection of methods generally used in experimental pharmacology to test compounds with different activities in the cardiovascular system. There are many models in vitro and in vivo and we have highlighted those used in the field of natural …

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Activity Methods For Animal Pharmacokinetic and Pharmacodynamic Studies

Rosangela Montanaro, Francesco Μaione, Vincenzo Brancaleone

This chapter provides an overview of the main features that need to be assessed with respect to the general pharmacology (pharmacokinetics, PK; pharmacodynamics, PD) of all molecules, including natural compounds. Here, the attention has been focused on bioavailability, the volume of distribution, …

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