Discovery and characterization of trypanocidal cysteine protease inhibitors from the ‘malaria box’
Glaécia A. N. Pereira, Elany B. da Silva, Saulo Fehelberg Pinto Braga, Paulo Gaio Leite et autres
Chagas disease, Human African Trypanosomiasis, and schistosomiasis are neglected parasitic diseases for which new treatments are urgently needed. To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain …
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24 citations
European Journal of Medicinal Chemistry