Lisa S. Robison

Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI mice

Victoria Pulido‐Correa, Ariana Hernandez, Eleanor Wind, Yingying Zhu et autres

BackgroundThe ketogenic diet (KD), characterized by high-fat, low-carbohydrate, and moderate protein intake, has gained attention for its therapeutic potential in patients with neurodegenerative diseases, including Alzheimer's disease (AD). Studies in AD rodent models report that KD and/or ketogenic supplements attenuate cognitive-behavioral impairments, …

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Cognitive Function and Hypertension

Natalia Motzko Noto, Betsi Reinosa Corrada, Lisa S. Robison, Robert Charles Speth

Given the brain’s high energy demands, the blood supply to the brain is critical for its function. Hence the importance of an intact brain vascular system to adequately perfuse the brain to sustain cognitive function. Given the damage to the vascular system …

Cerebral amyloid angiopathy: a narrative review

Natalia Motzko Noto, Robert C. Speth, Lisa S. Robison

Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the accumulation of amyloid-beta (Aβ) in the walls of cerebral vessels. It is commonly associated with cognitive decline, cerebral hemorrhage, and other neurological pathologies. Despite its prevalence and impact, there are currently …

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Abstract Fri174: Long Noncoding RNA MALAT1 -Mediated Cardiac and Mitochondrial Adaptations Under Ketotic Conditions in Mice and Human Cardiomyocytes

J. A. H. Murray, Talan Tran, Colin Pulickathadam, Sara Faruqui et autres

Background: Heart failure is characterized by mitochondrial dysfunction and energy deficits. Ketone bodies help mitigate cardiac remodeling and inflammation, while long noncoding RNAs (lncRNAs) regulate cardiac remodeling and mitochondrial metabolism. This study investigates how ketotic conditions influence lncRNA regulation and mitochondrial protection …

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Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT 1 Receptor Expression

Natalia Motzko Noto, Lisa S. Robison, Robert C. Speth

Abstract Introduction The renin-angiotensin-aldosterone system (RAAS) has been shown to be dysregulated in dementia, with elevated levels of angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptors (AT 1 Rs). Cerebral amyloid angiopathy (CAA), a common cerebrovascular disease, currently …

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Epigenetic regulation by ketone bodies in cardiac diseases and repair

Narasimman Gurusamy, J. A. H. Murray, Robert C. Speth, Lisa S. Robison

Ketone bodies, particularly β-hydroxybutyrate (BHB), play an important role in the epigenetic regulation of gene expression in cardiac tissues, impacting both cardiac health and disease. This review explores the multifaceted influence of ketone bodies on epigenetic mechanisms, including histone acetylation, DNA methylation, …

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Telmisartan and Lisinopril Show Potential Benefits in Rescuing Cognitive-Behavioral Function Despite Limited Improvements in Neuropathological Outcomes in Tg-SwDI Mice

Natalia Motzko Noto, Yazmin M. Restrepo, Ariana Hernandez, Chana Vogel et autres

Abstract Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease that results from beta-amyloid (Aβ) accumulation in the vessel walls that is associated with cognitive impairment and other neurological pathologies. There are currently no medications approved to treat CAA. This study investigated whether …

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Beyond expectations: investigating nilotinib’s potential in attenuating neurodegeneration in Alzheimer’s disease

Darcy Tocci, Vanya Gupta, Peter Kim, Jean J. Latimer et autres

Neurodegenerative diseases, such as Alzheimer's disease (AD), pose a formidable global challenge. While therapeutic options are available, their limitations are significant, necessitating the development of innovative treatment approaches. Here, we highlight the importance of repurposing drugs and discuss the future of drug …

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Effects of ketogenic diet on metabolic and cognitive‐behavioral outcomes in a mouse model of cerebral amyloid angiopathy

Victoria Pulido‐Correa, Chana Vogel, Lauren Rosenberg, Begoña Echeverría et autres

BACKGROUND: Cerebral amyloid angiopathy (CAA), characterized by the accumulation of amyloid protein in the cerebral vasculature, is highly prevalent in Alzheimer's disease (AD) patients and, on its own, increases the risk of hemorrhagic stroke, cognitive impairment, and dementia. Currently, there are no …

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Repurposing renin‐angiotensin system‐targeting medications for treatment of cerebral amyloid angiopathy and associated cognitive‐behavioral deficits in Tg‐SwDI mice

Ariana Hernandez, Natalia Motzko Noto, Chana Vogel, Iliana Uribe et autres

Abstract Background Cerebral amyloid angiopathy (CAA), the accumulation of amyloid proteins in the cerebral vasculature, increases the risk of stroke and vascular cognitive impairment and dementia (VCID). Not only is there no treatment for CAA, but the condition is also highly comorbid …

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Effects of Menopause and High Fat Diet on Metabolic Outcomes in a Mouse Model of Alzheimer’s Disease

Charly Abi-Ghanem, Abigail E. Salinero, Rachel M. Smith, Richard D. Kelly et autres

Background: About two-thirds of those with Alzheimer's disease (AD) are women, most of whom are post-menopausal. Menopause accelerates dementia risk by increasing the risk for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic disease (obesity, diabetes/prediabetes) is a well-known risk factor for dementia. …

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Abstract Tu133: Cardiac Adaptations and Mitochondrial Protection Through Long Noncoding RNAs Regulation in Mice on a Ketogenic Diet

Talan Tran, Natalia Motzko Noto, Ariana Hernandez, Victoria Pulido‐Correa et autres

Background: Heart failure, characterized by a metabolic imbalance, leads to impaired mitochondrial ATP production. Ketone bodies not only serve as an alternate energy source but also mitigate heart failure by reducing cardiac remodeling and inflammation. The role of long noncoding RNAs (lncRNAs) …

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