Trang T. T. Truong

The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC ‐Derived Cortical Networks From People With Bipolar Disorder

Bruna Panizzutti, Chiara C. Bortolasci, Megan K. Ellis, Briana Spolding et autres

BACKGROUND: Induced pluripotent stem cell (iPSC)-derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations. In …

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The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC ‐Derived Cortical Networks From People With Bipolar Disorder

Bruna Panizzutti, Chiara C. Bortolasci, Megan K. Ellis, Briana Randall et autres

ABSTRACT Background Induced pluripotent stem cell (iPSC)‐derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations. …

iPSC-Derived Myogenic Progenitor Cells from People with ME/CFS Reveal Altered Genes and Pathways with Drug Repurposing Potential

Dao Nguyen, Trang T. T. Truong, Bruna Panizzutti, Megan Ellis et autres

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Maternal Metformin Exposure Induces Gut Microbial Shifts in Non-Diabetic Dams and Sex-Stratified Changes in Mouse Offspring

Dat Da Ly, Kate Phuong-Nguyen, Trang T. T. Truong, Bryony A. McNeill et autres

Beyond being one of the most widely prescribed medications for type 2 diabetes, metformin has been increasingly used during pregnancy for gestational diabetes and polyendocrine metabolic ovarian syndrome. While it is considered safe for pregnancy and lactation, metformin is known to induce …

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Maternal Metformin Exposure Induces Gut Microbial Shifts in Non-Diabetic Dams and Sex-Stratified Changes in Mouse Offspring

Dat Da Ly, Kate Phuong-Nguyen, Trang T. T. Truong, Bryony A. McNeill et autres

Beyond being one of the most widely prescribed medications for type 2 diabetes, metformin has been increasingly used during pregnancy for gestational diabetes and polyendocrine metabolic ovarian syndrome. While it is considered safe for pregnancy and lactation, metformin is known to induce …

The toll-like receptor signalling pathway is altered in iPSC-derived cortical networks from people with bipolar disorder

Bruna Panizzutti, Chiara C. Bortolasci, Megan Ellis, Briana Spolding et autres

Abstract Background Induced pluripotent stem cell (iPSC)-derived brain cells are widely utilized as in vitro models for several neuropsychiatric disorders, as they retain the donor’s genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations. …

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Towards Mechanism‐Informed Treatments for Mental Health

Iker Bengoetxea de Tena, Farhanah N. Sallie, Arvie Abiero, Beatrice Rizzi et autres

Neuropsychiatric disorders represent a significant global health burden. Despite decades of research, current treatments typically provide only symptomatic relief, rather than addressing the underlying mechanisms of these conditions. Historically, research focused on the dopaminergic and serotonergic systems, which are deeply involved in …

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Towards Mechanism-Informed Treatments for Mental Health

I Bengoetxea de Tena, FN Sallie, A Rodriguez Abiero, B Rizzi et autres

Neuropsychiatric disorders represent a significant global health burden. Despite decades of research, current treatments typically provide only symptomatic relief, rather than addressing the underlying mechanisms of these conditions. Historically, research focused on the dopaminergic and serotonergic systems, which are deeply involved in …

Melatonin in bipolar disorder

Roger B. Varela, Trang T. T. Truong, Ken Walder, Michael Berk et autres

A major obstacle to the development of effective medications for bipolar disorder (BD) is the incomplete understanding of BD pathophysiology, as therapeutics that target the causal mechanisms underpinning BD are more likely to fully address symptoms and prevent recurrence of the disease. …

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Psychotropic pharmacogenetics in adult populations: From basic science to clinical trials and health economics – An evidence-based overview for decision makers

Trang T. T. Truong, Juliana Lago, Fiona Wilkes, Russell Barnes et autres

Psychotropic pharmacogenetics (PGx) offers significant potential advancements in psychiatric care by optimising medication selection and dosing based on genetic factors. This perspective article highlights the clinical utility, health economic implications and implementation challenges of psychotropic PGx, proposing that its broader implementation could …

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Effect of antipsychotics on the focal adhesion pathway

Bruna Panizzutti, Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai et autres

Focal adhesions and their dynamic nature are essential for various physiological processes, including the formation of neurites, synaptic function and plasticity. Alterations in these processes have been associated with schizophrenia and bipolar disorder. OBJECTIVES: This study aimed to explore the impact of …

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Associations between methamphetamine use disorder and SLC18A1 , SLC18A2 , BDNF , and FAAH gene sequence variants and expression levels

Alexandre A. Guerin, Briana Spolding, Kiymet Bozaoglu, Courtney Swinton et autres

Introduction Assessing candidate gene sequence variations and expression helps to understand methamphetamine use disorder and inform potential treatments. We investigated single nucleotide polymorphisms (SNPs) and gene expression in four candidate genes: SLC18A1, SLC18A2, BDNF, and FAAH, between controls and people with methamphetamine …

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