Piper Alyea-Herman

Heterozygous truncating variants in BICC1 are a novel cause of autosomal-dominant tubulointerstitial kidney disease

Naomi S Eylath, Kendrah Kidd, Piper Alyea-Herman, Julia Meyersiek et autres

Abstract Introduction Autosomal-dominant tubulointerstitial kidney disease (ADTKD) is characterized by chronic kidney disease (CKD) with an average age of end-stage renal disease (ESRD) of approximately 45 years, bland urinary sediment, the absence of proteinuria and autosomal dominant inheritance. While several causative genes …

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Abstract 2130 Construction of a synthetic mycobacterium phage genome using gene editing and transformation-associated recombination (TAR) cloning in Saccharomyces cerevisiae

Piper Alyea-Herman, Precious Ologuntere, Ari Metcalf, Jennifer Roecklein‐Canfield

The rise of antibiotic resistance in pathogenic bacteria is driving a renewed interest in bacteriophages. These naturally occurring antimicrobial agents can potentially be exploited as novel therapeutic agents. Existing limitations such as bacterial resistance and narrow host range; however, are problematic. The …

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Abstract 2192: Design and construction of a synthetic mycobacterium phage genome using transformation-associated recombination (TAR) cloning in Saccharomyces cerevisiae

Piper Alyea-Herman, Debora Edouard, Makayla Martorana, Jennifer Roecklein‐Canfield