Hellmut G. Augustin

Haemodynamic control of zonated liver function via instructive vascular Wnt signalling

Ki Hong Lee, Moritz Jakab, Alexey Uvarovskii, Dimitris Papageorgiou et autres

The vascular endothelium forms a systemically disseminated organ that translates micromilieu factors into instructive cues, designated as angiocrine signalling. While vascular control of organ function mechanisms have been discovered in essentially all major organs, the mechanisms of translating milieu factors into angiocrine …

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LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis

X Zhang, Miki Kamiyama, Margaret Tulessin, Lorna Wessels et autres

Combination therapies involving vascular targeting drugs have shown promise in overcoming resistance to immunotherapy. However, the prerequisite for vascular modulation to evoke an effective antitumor T-cell response remains elusive. Tracing the transcriptional response of liver metastasis-associated peritumoral and tumor endothelial cells (TEC) …

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Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Vera Skafar, Izadora de Souza, Biplab Ghosh, Ancély Ferreira dos Santos et autres

Abstract Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. More recently, ferroptosis suppressor protein 1 (FSP1) was identified as a critical ferroptosis inhibitor, acting …

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Riboflavin metabolism shapes FSP1-driven ferroptosis resistance

Skafar Vera, Izadora de Souza, Ghosh Biplab, Ancely Ferreira dos Santos et autres

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. More recently, ferroptosis suppressor protein 1 (FSP1) was identified as a critical ferroptosis inhibitor, acting via …

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 3

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 6

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 5

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 4

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 1

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Chanté D. Mayer et autres

Supplementary Movie 2

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

Martín Hugo, Lissy Z. F. Gross, Andresa Messias, Lucía Alcober-Boquet et autres

Abstract Ferroptosis, an iron-dependent form of oxidative cell death, is predominantly regulated by glutathione peroxidase 4 (GPX4), making it a promising target for cancer therapy. However, the majority of GPX4 inhibitors, most of which contain a chloroacetamide moiety such as RSL3, are …

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