Kyoichi Isono

Regulation of IgE-Mediated Allergic Reactions by Disulfide-Linked Multimers of Histamine-Releasing Factor

Yu Kawakami, Tomoaki Ando, Ryoji Ito, Kazumi Kasakura et autres

Background: Stimulation with allergen and allergen-specific IgE activates mast cells, leading to allergic reactions. We studied how the recently defined alarmin, Histamine-Releasing Factor (HRF), promotes this immune response. Methods: HRF reactivity to IgE and other Ab isotypes was analyzed by in-vitro binding …

us, jp, kr, fr, br, de (code pays fourni par la source)

Activation of Transient Receptor Potential Vanilloid 1 Is Involved in Both Pain and Tumor Growth in a Mouse Model of Cancer Pain

Akari Yoshida, Masayuki Nishibata, Tomoyuki Maruyama, Shogo Sunami et autres

Activation of calcitonin gene-related peptide (CGRP)-positive sensory neurons in the tumor microenvironment has been shown to be involved in tumor growth. However, how CGRP-positive sensory neurons are activated requires elucidation. In this study, we focused on transient receptor potential vanilloid 1 (TRPV1) …

jp (code pays fourni par la source)

Increased infiltration of CD4+ T cell in the complement deficient lymphedema model

Toshihiko Nishioka, Keiichi Katayama, Shinji Kumegawa, Kyoichi Isono et autres

Abstract Background Lymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can lead to impaired joint mobility in the extremities and reduced quality of life. Chronic inflammation due to …

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53 Increased infiltration of CD4+ T cell in the complement deficient lymphedema model

Toshihiko Nishioka, Keiichi Katayama, Shinji Kumegawa, Kyoichi Isono et autres

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Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure

Masahiro Oka, Mayumi Otani, Yoichi Miyamoto, Rieko Oshima et autres

NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' function in controlling gene expression remains elusive. Here, we demonstrate that the nuclear bodies of NUP98::HOXA9 and SET::NUP214 promote …

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PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment

Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif et autres

Polycomb group proteins (PcG), polycomb repressive complexes 1 and 2 (PRC1 and 2), repress lineage inappropriate genes during development to maintain proper cellular identities. It has been recognized that PRC1 localizes at the replication fork, however, the precise functions of PRC1 during …

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Androgen/Wnt/β‐catenin signal axis augments cell proliferation of the mouse erectile tissue, corpus cavernosum

Mizuki Kajimoto, Kentaro Suzuki, Yuko Ueda, Kota Fujimoto et autres

Abstract The murine penile erectile tissues including corpus cavernosum (CC) are composed of blood vessels, smooth muscle, and connective tissue, showing marked sexual differences. It has been known that the androgens are required for sexually dimorphic organogenesis. It is however unknown about …

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Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Toshitada Takemori, Akiko Sugimoto-Ishige, Hironori Nishitsuji, Yushi Futamura et autres

A number of entry inhibitors are being developed to enhance the treatment of HBV patients with oral nucleoside/nucleotide analogues (NA). To amplify the effectiveness of NA therapy, several efforts have been made to develop therapeutic MAbs with neutralizing activity against HBs antigens. …

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Development of Surgical and Visualization Procedures to Analyze Vasculatures by Mouse Tail Edema Model

Shinji Kumegawa, Gen Yamada, Daiki Hashimoto, Tsuyoshi Hirashima et autres

BACKGROUND: Because of the high frequency of chronic edema formation in the current "aged" society, analyses and detailed observation of post-surgical edema are getting more required. Post-surgical examination of the dynamic vasculature including L.V. (Lymphatic Vasculature) to monitor edema formation has not …

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Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes

Daiki Kajioka, Kentaro Suzuki, Shoko Matsushita, Shinjiro Hino et autres

Significance Androgen plays essential roles for sex differentiation of external genitalia through regulating male-biased genes. Even females can differentiate into male-type external genitalia depending on the degree of androgenic exposure. However, the mechanisms underlying androgen responsiveness in females are poorly defined. Here, …

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Augmentation of Stimulator of Interferon Genes–Induced Type I Interferon Production in COPA Syndrome

Takashi Kato, Masaki Yamamoto, Yoshitaka Honda, Takashi Orimo et autres

Objective Coatomer subunit alpha (COPA) syndrome, also known as autoinflammatory interstitial lung, joint, and kidney disease, is caused by heterozygous mutations in COPA. We identified a novel COPA variant in 4 patients in one family. We undertook this study to elucidate whether …

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Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Joonbeom Bae, Sang-Pil Choi, Kyoichi Isono, Ji Yoon Lee et autres

The timely mobilization of hematopoietic stem and progenitor cells (HSPCs) is essential for maintaining hematopoietic and tissue leukocyte homeostasis. Understanding how HSPCs migrate between bone marrow (BM) and peripheral tissues is of great significance in the clinical setting, where therapeutic strategies for …

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