Araceli Visentín

Protein– RNA condensation kinetics via filamentous nanoclusters

Ramón Peralta Martínez, Araceli Visentín, Mariano Salgueiro, Silvia Susana Borkosky et autres

Protein-RNA phase separation is at the center of membraneless biomolecular condensates governing cell physiology and pathology. Using an archetypical viral protein-RNA condensation model, we determined the sequence of events that starts with sub-second formation of a protomer with two RNAs per protein …

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Protein-RNA condensation kinetics via filamentous nanoclusters

Ramón Peralta Martínez, Araceli Visentín, Mariano Salgueiro, Silvina S. Borkosky et autres

Abstract Protein-RNA phase separation is at the center of membraneless biomolecular condensates governing cell physiology and pathology. Using an archetypical viral protein-RNA condensation model, we determined the sequence of events that starts with sub-second formation of a protomer with two RNAs per …

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Assembly of the Tripartite and RNA Condensates of the Respiratory Syncytial Virus Factory Proteins In Vitro: Role of the Transcription Antiterminator M2-1

Araceli Visentín, Nicolás Demitroff, Mariano Salgueiro, Silvia Susana Borkosky et autres

A wide variety of viruses replicate in liquid-like viral factories. Non-segmented negative stranded RNA viruses share a nucleoprotein (N) and a phosphoprotein (P) that together emerge as the main drivers of liquid–liquid phase separation. The respiratory syncytial virus includes the transcription antiterminator …

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Molten Globule Driven and Self-downmodulated Phase Separation of a Viral Factory Scaffold

Mariano Salgueiro, Gabriela Camporeale, Araceli Visentín, Martı́n Arán et autres

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Molten globule driven and self-downmodulated phase separation of a viral factory scaffold

Mariano Salgueiro, Gabriela Camporeale, Araceli Visentín, Martı́n Arán et autres

Viral factories of liquid-like nature host transcription and replication in most viruses. The syncytial respiratory virus factories include gene function proteins, brought together by the phosphoprotein (P) RNA polymerase cofactor, present across non-segmented negative stranded RNA viruses. Homotypic liquid-liquid phase separation of …

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Deconstructing virus condensation

Nora López, Gabriela Camporeale, Mariano Salgueiro, Silvia Susana Borkosky et autres

Viruses have evolved precise mechanisms for using the cellular physiological pathways for their perpetuation. These virus-driven biochemical events must be separated in space and time from those of the host cell. In recent years, granular structures, known for over a century for …

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Molten Globule Driven Liquid-Liquid Phase Separation at the Center of Viral Factory Assembly

Mariano Salgueiro, Gabriela Camporeale, Julieta Conci, Belén Sousa et autres

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