Kirk Kee

Narcolepsy type 1 following immune checkpoint inhibitor therapy for metastatic melanoma

Aiden Cushnahan, Su Hii, Kirk Kee, Megan Rees et autres

Narcolepsy is a rare disorder of central hypersomnolence which is often under-recognised owing to a variable clinical phenotype. Narcolepsy type 1 (NT1) is caused by loss of hypothalamic hypocretin (orexin) secreting neurons, which function to maintain wakefulness. There is strong evidence that …

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A pilot, parallel-group, blinded, placebo-controlled, randomiseD, pRagmatic clinical trial investigating the Effect of temazepAM on objective and subjective measures of sleep in critically ill patients (the DREAM trial)

Laurie Showler, Yasmine Ali Abdelhamid, Melissa J. Ankravs, Jeremy Goldin et autres

Objective: Patients in the intensive care unit (ICU) suffer from disturbed sleep and pharmacological sleep aids are frequently prescribed despite limited data on their efficacy. The objective of this study was to assess the effect of a single nocturnal dose of the …

au (code pays fourni par la source)

The Impact of Weight Loss on the Physiological Endotypes Associated With OSA

Caroline Beatty, Ai-Ming Wong, Shane A. Landry, Luke D. J. Thomson et autres

Background Weight loss improves upper airway collapsibility in people with OSA. However, it is unclear how weight loss affects the other physiological traits (ie, endotypes) associated with OSA (loop gain, arousal threshold, and muscle compensation). Research Questions What is the effect of …

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P089 12 month experience of a subsidised mandibular advancement splint program.

Aiden Cushnahan, Huailiang Tan, A Gikas, Alan Christopher Perkins et autres

Abstract Background Obstructive sleep apnoea (OSA) is a common condition with the potential for significant morbidity and mortality. Mandibular advancement splints (MAS) are an alternative to continuous positive airway pressure in appropriately selected patients. In 2024, our sleep service formalised a subsidised …

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P098 A rare case of immunotherapy induced narcolepsy with cataplexy.

Aiden Cushnahan, Su Hii, Kirk Kee, Peter D. Wallbridge

Abstract Background Narcolepsy is a rare disorder of central hypersomnolence which is often under diagnosed largely owing to a variable clinical phenotype. There is strong evidence that type 1 narcolepsy (NT1) is an immune-mediated disorder given the association with the class II …

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P084 Does OSA endotype impact the incidence of atrial fibrillation and the severity of atrial remodelling? A retrospective cohort study.

Benjamin M. Robinson, Aiden Cushnahan, Jeremy Stonehouse, Alan Christopher Perkins et autres

Abstract Background Multiple studies have suggested that the prevalent sleep disorder obstructive sleep apnoea (OSA) plays a key role in initiating and progressing atrial fibrillation (AF) as well as impacting the response to arrhythmia pharmaco- and ablative therapy. The mechanisms underlying how …

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P055 Impact of humidification on bacterial filters and delivered pressures of PAP devices

Aiden Cushnahan, Jeremy Stonehouse, Alan Christopher Perkins, S Dayal et autres

Abstract Background In typical sleep laboratories, PAP devices are used on multiple patients in short periods of time. Some manufacturers recommend the use of bacterial filters to prevent cross contamination. Bacterial filters are known to increase resistance and reduce delivered pressures, especially …

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P008 Sleep in the ICU: comparing PSG & structured observation

Alan Christopher Perkins, Laurie Showler, Yasmine Ali Abdelhamid, Melissa J. Ankravs et autres

Abstract Introduction Patients in Intensive Care Units (ICU) frequently suffer from disturbed sleep and are often prescribed sleep-promoting medications. Assessing the effectiveness of these medications in the ICU by polysomnography (PSG) is difficult due to atypical sleep EEG patterns and is intrusive …

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P007 Evaluating concordance of actigraphy and sleep-diaries in a clinical setting

Catherine Wilson, Jeremy Stonehouse, Alan Christopher Perkins, Aiden Cushnahan et autres

Abstract Introduction Actigraphy and sleep diaries are recommended by both the ICSD-3 and AASM. However, actigraphy provides a significant operational burden. We aimed to evaluate concordance between these tests. Methods 60 sleep studies with concurrent Actigraphy and sleep diaries were sampled. Total …

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A Parallel-Group, Blinded, Placebo-Controlled, Randomised, Pragmatic Clinical Trial Investigating the Effect of Temazepam on Objective and Subjective Measures of Sleep in Critically Ill Patients (The DREAM Trial)

Laurie Showler, Yasmine Ali Abdelhamid, Melissa J. Ankravs, Jeremy Goldin et autres

Abstract Rationale: Patients in the Intensive Care Unit (ICU) suffer disturbed sleep and pharmacological sleep aids are frequently prescribed despite a lack of trials supporting their use. The aim of this study was to assess the effect of a benzodiazepine, temazepam, on …

au (code pays fourni par la source)

A parallel-group, blinded, placebo-controlled, randomised, pragmatic clinical trial investigating the effect of temazepam on objective and subjective measures of sleep in critically ill patients (the dream trial)

Laurie Showler, Yasmine Ali Abdelhamid, Melissa J. Ankravs, Jeremy Goldin et autres

au (code pays fourni par la source)

P033 Validation of GENEActiv actimeters and Cicada Actigraphy Suite in a clinical sleep laboratory setting.

Clare Wilson, Megan Rees, Kirk Kee, Jeremy Stonehouse et autres

Abstract Introduction The use of Actigraphy in clinical settings is an established approach, with the American Academy of Sleep Medicine (AASM) describing actigraphy as a suggested aid in the diagnosis of multiple sleep disorders such as delayed sleep phase syndrome, narcolepsy and …

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