Carla Cicchini

Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States

Laura Amicone, Carla Cicchini, Fabio Petti, Alessandra Marchetti

Cellular plasticity allows organisms to adapt dynamically to both physiological and pathological contexts. Epithelial-mesenchymal transition (EMT) is a well-known example of this plasticity and is now widely recognized as a reversible and highly dynamic spectrum of cellular states rather than a simple …

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HNF4α as a Master Regulator of Epigenetic Dynamics in Epithelial Cells

Laura Amicone, Carla Cicchini, Alessandra Marchetti

Hepatocyte nuclear factor 4 α (HNF4α) is a master transcriptional regulator essential for the maintenance of epithelial cell identity and function. Beyond its well-established role in controlling metabolic and differentiation programs, recent evidence highlights HNF4α as a key determinant of epithelial epigenetic …

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Author response: Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

This article makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs.The findings are convincing and advance our understanding of RNA-binding proteinmediated miRNA sorting, providing …

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Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …

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Author response: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …

Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

Abstract While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, …

it, us (code pays fourni par la source)

Author response: Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …

Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

Abstract While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, …

it, us (code pays fourni par la source)

Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

Abstract While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, …

it, us (code pays fourni par la source)

Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, although …

it, us (code pays fourni par la source)

Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni et autres

ABSTRACT While it is accepted that Extracellular Vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and dynamic miRNA-loading in EVs is still limited to few specific RNA-binding proteins interacting with sequence determinants. Moreover, …

it (code pays fourni par la source)

The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity

Laura Amicone, Alessandra Marchetti, Carla Cicchini

The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that endows epithelial cells with mesenchymal properties, including motility and invasion capacity; therefore, its aberrant reactivation in cancerous cells represents a critical step to gain a metastatic phenotype. The EMT is a dynamic program …

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