Vanessa Vieira

Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

Abstract Neurodegeneration is a major driver of disability in multiple sclerosis (MS), the most common chronic inflammatory disease of the central nervous system (CNS) 1 . Retinal ganglion cells (RGCs), a heterogeneous neuronal population in the eye, undergo degeneration in MS and …

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Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

This repository contains the processed single-nucleus RNA sequencing data underlying the manuscript "Intracellular complement factor H protects neurons during CNS inflammation". The dataset includes raw count matrices after quality control and corresponding cell-level metadata for human retinal ganglion cells from control donors …

Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

This repository contains the processed single-nucleus RNA sequencing data underlying the manuscript "Intracellular complement factor H protects neurons during CNS inflammation". The dataset includes raw count matrices after quality control and corresponding cell-level metadata for human retinal ganglion cells from control donors …

Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration

Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira et autres

Abstract Extracellular adenosine triphosphate (ATP) and diphosphate (ADP) act as key signalling molecules in the central nervous system (CNS) and regulate neuroinflammatory responses through purinergic receptors. Although astrocytes and neurons undergo profound changes in signalling and metabolism during inflammation, the contribution of …

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Additional file 1 of Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration

Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira et autres

Supplementary Material 1.

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Additional file 1 of Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration

Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira et autres

Supplementary Material 1.

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Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration

Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira et autres

Abstract Extracellular adenosine triphosphate (ATP) and diphosphate (ADP) act as key signalling molecules in the central nervous system (CNS) and regulate neuroinflammatory responses through purinergic receptors. Although astrocytes and neurons undergo profound changes in signalling and metabolism during inflammation, the contribution of …

de (code pays fourni par la source)

Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration

Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira et autres

Abstract Extracellular adenosine triphosphate (ATP) and diphosphate (ADP) act as key signalling molecules in the central nervous system (CNS) and regulate neuroinflammatory responses through purinergic receptors. Although astrocytes and neurons undergo profound changes in signalling and metabolism during inflammation, the contribution of …

de (code pays fourni par la source)

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis

Sina C. Rosenkranz, Joana F. da Rocha, Luis Moreira, Pius Schlachter et autres

Aerobic exercise is a disease-modifying intervention in multiple sclerosis (MS) that ameliorates several progressive neurological symptoms in people with MS. Here we show that the exercise hormone irisin mediates neuroprotective effects of exercise in the experimental autoimmune encephalomyelitis (EAE) mouse model of …

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Targeting endometrial stem cell in endometriosis treatment, a scoping review

Maria João Carvalho, Fernanda Santos, Vanessa Vieira, Bárbara Laranjeiro et autres

INTRODUCTION: Endometriosis is characterized by the ectopic implantation of endometrial tissue affecting reproductive-aged women. Available therapies have still unmet needs namely due to recurrence rates and systemic side effects. Emerging evidence suggests endometrial stem cells (EnSCs) contribution in disease pathogenesis, including mesenchymal …

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A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation

Jana K. Sonner, Audrey Kahn, Lars Binkle-Ladisch, Jan Broder Engler et autres

Inflammatory activity during multiple sclerosis (MS) often improves during pregnancy, suggesting that pregnancy-related immune adaptations affect the disease. Here we show that growth/differentiation factor-15 (GDF-15) increases during pregnancy and correlates with a reduced rate of MS relapses. GDF-15 also accumulates in the …

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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Marcel S. Woo, Johannes Brand, Lukas C. Bal, Manuela Moritz et autres