Veronika Kloboves-Prevodnik

Complementary detection strategies for circulating tumor cells in breast cancer: clinical implications of combining immunofluorescence and cytopathological staining

Tanja Jesenko, Cvetka Grašič Kuhar, Ziva Pisljar, Simona Miceska et autres

Background: Circulating Tumor Cells (CTCs) serve as important biomarkers for disease monitoring and treatment response in patients with metastatic breast cancer. Their detection remains challenging because of their low abundance, phenotypic diversity and non-standardized mode of detection. Cytopathological Giemsa and Immunofluorescence (IF) …

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The Genetic Landscape of Primary Breast Marginal Zone Lymphoma Identifies a Mutational-driven Disease With Similarities to Ocular Adnexal Lymphoma

Vanesa‐Sindi Ivanova, Thomas Menter, Joel Zaino, Kirsten D. Mertz et autres

Extranodal marginal zone lymphomas (eMZL) can occur in any organ and site of the body. Recent research has shown that they differ from organ to organ in terms of their mutational profile. In this study, we investigated a cohort of primary breast …

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The prognostic significance of programmed cell death protein 1 and its ligand on lymphoma cells and tumor-immune cells in diffuse large B-cell lymphoma, not otherwise specified

Teja Cas Slak, Simona Miceska, Gorana Gašljević, Lučka Boltežar et autres

BACKGROUND: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) is the most common type non-Hodgkin's lymphoma, where the treatment of relapsed/refractory cases is the major challenge. Programmed cell death protein 1 (PD-1) and its ligand PD-L1 play a crucial role in …

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81 Cytological samples for detection of BRCA 1/2 mutations in patients with high grade serous ovarian cancer

Erik Škof, Srdjan Novaković, Vida Stegel, Simona Miceska et autres

Introduction/Background* Since approval of PARP inhibitor olaparib, testing for germline BRCA 1/2 (gBRCA) gene mutations from blood and testing from formalin-fixed-paraffin-embedded (FFPE) tumor tissue for detection of somatic BRCA 1/2 (sBRCA) gene mutation has become standard procedure for patients with high-grade serous …

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Morphological features of breast cancer circulating tumor cells in blood after physical and biological type of isolation

Tanja Jesenko, Živa Modic, Cvetka Grašič Kuhar, Maja Čemažar et autres

BACKGROUND: Circulating tumor cells (CTCs) have become an important biomarker in breast cancer. Different isolation tech-niques based on their biological or physical features were established. Currently, the most widely used methods for visualization after their separation are based on immunofluorescent staining, which …

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Posodobljena priporočila diagnostike in zdravljenja diferenciranega raka ščitnice

Alenka Grošel, Andraž Perhavec, Andrej Doma, Andreja A. Schwarzbartl-Pevec et autres

Bystander Effect Induced by Electroporation is Possibly Mediated by Microvesicles and Dependent on Pulse Amplitude, Repetition Frequency and Cell Type

Ajda Prevc, Apolonija Bedina Zavec, Maja Čemažar, Veronika Kloboves-Prevodnik et autres

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Grading of follicular lymphoma in cytological samples

Ulrika Klopĉiĉ, Jaka Lavrenčak, Gorana Gašljević, Matej Bračko et autres

OBJECTIVE: The treatment of follicular lymphoma (FL) depends on its grade. The current World Health Organization (WHO) 2008 Classification of Tumours of Haematopoietic and Lymphoid Tissues recommends the grading of FL on histological samples according to the Mann and Berard method, taking …

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Hodgkin’s lymphoma is a rare form of clonal haematological non-mast cell disease in systemic mastocytosis

Gorana Gašljević, Biljana Grcar-Kuzmanov, Alenka Grošel, Matjaž Sever et autres

BACKGROUND: The association of systemic mastocytosis (SM) with a non-mast cell haematological neoplasm represents a specific subtype of mastocytosis termed systemic mastocytosis with associated haematological non-mast cell disease (SM-AHNMD). The overwhelming majority of the associated neoplasms are of myeloid origin, while lymphoid …

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Coexistent hairy cell leukaemia and hepatosplenic t-cell lymphoma: a case report

Gorana Gašljević, Veronika Kloboves-Prevodnik, Barbara Gazić, Marjeta Vovk

BACKGROUND: Hairy cell leukaemia (HCL) is a chronic B-cell leukaemia characterized by expansion of neoplastic cells in the spleen, bone marrow and blood. Symptoms of HCL are related to pancytopenia and immune deficiency. Patients with HCL have an increased risk of second …

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Citopatološka diagnostika limfomov iz vzorcev bezgavk

Veronika Kloboves-Prevodnik

S citopatološko preiskavo lahko hitro, poceni in zanesljivo diagnosticiramo bolezni bezgavk. Pogosto lahko že z mikroskopskim pregledom ugotovimo, ali gre za reaktivni limfadenitis, vnetje, zasevek ali limfom. Kadar to ni mogoče, si pomagamo z dodatnimi imunocitokemičnimi preiskavami in imunofenotipizacijo s pretočnim citometrom. …

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Survey of medical training in cytopathology carried out by the journal Cytopathology

Amanda Herbert, B Cochand‐Priollet, Paul Cross, Milind Y. Desai et autres

Anshu, A. Herbert, B. Cochand‐Priollet, P. Cross, M. Desai, R. Dina, J. Duskova, A. Evered, A. Farnsworth, W. Gray, S. S. Gupta, K. Kapila, I. Kardum‐Skelin, V. Kloboves‐Prevodnik, T. K. Kobayashi, H. Koutselini, W. Olszewski, B. Onal, M. B. Pitman, Ž. Marinšek, …

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