Rob A. Cairns

Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism

Sandy Che-Eun S. Lee, Andrea Hye An Pyo, Helia Mohammadi, Ji Zhang et autres

2-Aminoethanethiol dioxygenase (ADO) is a thiol dioxygenase that sulfinylates cysteamine and amino-terminal cysteines in polypeptides. The pathophysiological roles of ADO remain largely unknown. Here, we demonstrate that ADO expression represents a vulnerability in cancer cells, as ADO depletion led to loss of …

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Abstract SY31-02: Determinants of hypoxia in pancreatic cancer and identification of ULK1 as a potential therapeutic target

Ji Zhang, Dan Cojocari, Rob A. Cairns, Marianne Koritzinsky et autres

Abstract The effectiveness of radiation treatment is impacted by spatially defined features of the tumor microenvironment including areas of tumor hypoxia. This is due in part to direct protection against radiation damage by hypoxia, as well as through the influence of hypoxia …

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Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke et autres

AbstractPurpose: Tumor hypoxia is associated with poor response to radiation (RT). We previously discovered a novel mechanism of metformin: enhancing tumor RT response by decreasing tumor hypoxia. We hypothesized that metformin would decrease tumor hypoxia and improve cervical cancer response to RT. …

Supplementary Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke et autres

Supplementary Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Data from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke et autres

Abstract Proliferating cancer cells are characterized by high rates of glycolysis, lactate production, and altered mitochondrial metabolism. This metabolic reprogramming provides important metabolites for proliferation of tumor cells, including glioblastoma. These biological processes, however, generate oxidative stress that must be balanced through …

Data from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke et autres

Abstract Proliferating cancer cells are characterized by high rates of glycolysis, lactate production, and altered mitochondrial metabolism. This metabolic reprogramming provides important metabolites for proliferation of tumor cells, including glioblastoma. These biological processes, however, generate oxidative stress that must be balanced through …

Supplemental Figures from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke et autres

Supplemental Figure 1: Related to Figure 1: Characterization of Gene-Trapped Clones Supplemental Figure 2 Related to Figure 2: PINK1 alters normal astrocyte metabolism Supplemental Figure 3 Related to Figure 2: PINK1 alters normal astrocyte metabolism Supplemental Figure 4: Related to Figure 3: …

Data from Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

Rob A. Cairns, Kevin L. Bennewith, Edward E. Graves, Amato J. Giaccia et autres

Abstract Purpose: Solid tumors contain microenvironmental regions of hypoxia that present a barrier to traditional radiotherapy and chemotherapy, and this work describes a novel approach to circumvent hypoxia. We propose to overcome hypoxia by augmenting the effectiveness of drugs that are designed …

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Data from Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

Rob A. Cairns, Kevin L. Bennewith, Edward E. Graves, Amato J. Giaccia et autres

Abstract Purpose: Solid tumors contain microenvironmental regions of hypoxia that present a barrier to traditional radiotherapy and chemotherapy, and this work describes a novel approach to circumvent hypoxia. We propose to overcome hypoxia by augmenting the effectiveness of drugs that are designed …

ca, us (code pays fourni par la source)

Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke et autres

AbstractPurpose: Tumor hypoxia is associated with poor response to radiation (RT). We previously discovered a novel mechanism of metformin: enhancing tumor RT response by decreasing tumor hypoxia. We hypothesized that metformin would decrease tumor hypoxia and improve cervical cancer response to RT. …

Supplementary Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke et autres

Supplementary Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer

Suplemental methods from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke et autres

Suplemental methods for experiments appearing in supplemental data and expanded details from methods in main manuscript.