Steve D. Paget

Antitubercular Triazines: Optimization and Intrabacterial Metabolism

Xin Wang, Daigo Inoyama, Riccardo Russo, Shao-Gang Li et autres

us (code pays fourni par la source)

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

Xin Wang, Alexander L. Perryman, Shaogang Li, Steve D. Paget et autres

Tuberculosis, caused by Mycobacterium tuberculosis ( M. tuberculosis ), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pioneering a computer-aided discovery paradigm that merges structure-based virtual screening with ligand-based, machine learning methods …

us (code pays fourni par la source)

Abstract 2528: Optimization of small molecules targeting BMI1 protein expression. Part 2. Improved potency, oral bioavailability, and in vivo efficacy of amino-pyrazines and amino-pyridines

Ramil Baiazitov, Nadiya Sydorenko, Hongyu Ren, Wu Du et autres

Abstract Earlier, in our efforts to identify molecules that selectively deplete tumor stem cells, we discovered and elaborated on a series of amino-thiazoles. These first-in-class small molecule inhibitors reduce the activity and levels of BMI1 protein in vitro and in vivo (see …

us (code pays fourni par la source)

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery

Sean Ekins, Robert C. Reynolds, Hiyun Kim, Mi-Sun Koo et autres

us (code pays fourni par la source)

In Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457

Barbara D. Foleno, Darren Abbanat, Raul M. Goldschmidt, Robert K. Flamm et autres

RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of < or =4 microg/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.

us (code pays fourni par la source)