Srinadh Komanduri

Biliary Microbiome Dysbiosis Is Associated with Susceptibility to Post-ERCP Pancreatitis

Jonathan Y. Xia, Srinadh Komanduri, Rajesh N. Keswani, Terrance R. Rodrigues et autres

Abstract Background & Aims Pancreatitis remains the most common adverse event following endoscopic retrograde cholangiopancreatography (ERCP), yet current risk stratification relies primarily on clinical and procedural factors. The present study aims to examine bile-based microbiome signatures as a potential link between nonprocedure …

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Indomethacin with or without Prophylactic Pancreatic Stent Placement to Prevent Pancreatitis after ERCP: A Randomised Non-Inferiority Trial

B. Joseph Elmunzer, Sachin B. Wani, Valerie L. Durkalski‐Mauldin, Peter Higgins et autres

BACKGROUND: The combination of rectally administered indomethacin and placement of a prophylactic pancreatic stent is recommended to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) in high-risk patients. Preliminary evidence suggests that the use of indomethacin might eliminate or substantially reduce the need …

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Reply

DIANE B. WAYNE, Jeffrey H. Barsuk, Srinadh Komanduri

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A Machine-Based Learning Model for Recurrence Prediction and Timing After Endoscopic Eradication Therapy for Barrett’s Esophagus

Venkata S. Akshintala, Samuel S. Han, Yukun Yan, Raf Bisschops et autres

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Clinical Validation of a Simulation-Based Mastery Learning Curriculum for Colonoscopy and Polypectomy in Practicing Gastroenterologists

Srinadh Komanduri, Elaine R. Cohen, Ronak Vashi Patel, Rajesh N. Keswani et autres

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Recurrent Barrett’s esophagus-related neoplasia is uncommon after successful endoscopic eradication therapy over long-term follow-up

Thomas J. Enke, Sridevi K. Pokala, Colin Hensen, Case W. Brennan et autres

US-based data describing long-term outcomes following successful endoscopic eradication therapy (EET) for Barrett's esophagus (BE) is limited. We assessed the incidence of recurrent BE and BE-related neoplasia and factors associated with recurrent BE in a prospective cohort with long-term follow-up. Patients who …

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Integrating multi-omics in bile for biomarker discovery in cholangiocarcinoma

Jonathan Y. Xia, Srinadh Komanduri, Rajesh N. Keswani, Terrance R. Rodrigues et autres

BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive cancer with a poor prognosis. Histopathology evaluation of brushings and biopsies obtained during endoscopic retrograde cholangiopancreatography (ERCP) currently remains the main method of diagnosis, which has limited sensitivity for malignancy detection. Our study aimed to identify …

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Challenges in Endoscopic Eradication Therapy

Kevin P. Shah, Vismaya S. Bachu, Shirin A Dey, Domenico Farina et autres

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Over-The-Scope Clip Misdeployment Resulting in Acute Cholangitis and Biliary Pancreatitis

Aniruddha Srivastava, Luay Matthew Almassalha, Laurens P. Janssens, Srinadh Komanduri et autres

Over-the-scope clips (OTSCs) have improved the endoscopic management of acute nonvariceal upper gastrointestinal bleeding. They allow for effective hemostasis of high-risk lesions in challenging locations and have been shown to be superior to through-the-scope clips. However, misdeployment of OTSCs may be associated …

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Racial Disparities in Adherence to Quality Indicators in Barrett's Esophagus: An Analysis Using the GIQuIC National Benchmarking Registry

Sachin B. Wani, Blake Jones, J. Lucas Williams, Nicholas J. Shaheen et autres

INTRODUCTION: Racial disparities in outcomes in esophageal adenocarcinoma are well established. Using a nationwide registry, we aimed to compare clinical and endoscopic characteristics of blacks and whites with Barrett's esophagus (BE) and adherence to defined quality indicators. METHODS: We analyzed data from …

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High Quality Barrett’s Esophagus Examination and Endoscopic Eradication Therapy

Shirin A Dey, Kevin P. Shah, Srinadh Komanduri

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Improvement in documentation rates for resumption of antithrombotic agents after elective endoscopy using an electronic health record–based intervention

Jeffrey K. Than, Terrance R. Rodrigues, Mary Kwasny, Srinadh Komanduri

Background and Aims Resumption recommendations for anticoagulants (ACs) and antiplatelet agents (APAs) after endoscopy are inconsistently documented, which has been associated with a small but clinically significant number of adverse events (AEs). Clinical decision support systems must be implemented properly to ensure …

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