Robert Grecian

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Pranvera Sadiku, Alejandro J. Brenes, Rupert Laurenz Mayer, Leila Reyes et autres

Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Given that neutrophils are known to display a prominent discordance between mRNA and protein abundance, we developed …

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Multidisciplinary Prehabilitation Reduces Hospitalization Time and Suggests Improved Survival in Patients with Radiologically Diagnosed Lung Cancer

Iain Phillips, Abi Walton, Mark D. Stares, Peter S Hall et autres

Background/Objectives: Lung cancer is the commonest cause of cancer death worldwide. Treatment efficacy is improving, but treatment rates remain low. We aimed to assess the impact of tri-modality early prehabilitation (single in-person interventions by a senior doctor in palliative/supportive care, physiotherapist and …

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Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Pranvera Sadiku, Alejandro J. Brenes, Rupert Laurenz Mayer, Leila Reyes et autres

ABSTRACT Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Given that neutrophils are known to display a prominent discordance between mRNA and protein abundance, we …

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Early prehabilitation reduces admissions and time in hospital in patients with newly diagnosed lung cancer

Iain Phillips, Maria Deans, Abi Walton, Mahéva Vallet et autres

OBJECTIVES: Lung cancer is the leading cause of cancer death in the UK. Prehabilitation aims to maximise patient fitness and minimise the negative impact of anticancer treatment. What constitutes prehabilitation before non-surgical anticancer treatment is not well established. We present data from …

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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Leila Reyes, Manuel A. Sánchez-García, Tyler E. Morrison, Andy J. M. Howden et autres

Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key role in the lung injury …

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Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis

Pranvera Sadiku, Joseph A. Willson, Eilíse M. Ryan, David Sammut et autres

(Cell Metabolism 33, 411–423.e1–e4; February 2, 2021) In the originally published version of this article, an earlier draft of Figure 5 was mistakenly included. This has now been replaced with the final version, which includes data generated during the revision process. Updated …

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Emily Watts, Andrew J.M. Howden, Tyler E. Morrison, Pranvera Sadiku et autres

Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine neutrophils regulated expression of cell surface receptors, signal transduction networks, and metabolic machinery to …

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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Leila Reyes, Manuel A. Sánchez-García, Tyler E. Morrison, Andy J. M. Howden et autres

Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key role in the lung injury …

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S47 The NSCLC pleural metastatic environment influences the role neutrophils play in the immune checkpoint

Robert Grecian, Emily Gwyer Findlay, Kevin Dhaliwal, Adam Byron et autres

Introduction Raised blood neutrophil-to-lymphocyte ratio (NLR) correlates with worse outcomes in NSCLC. Increasing evidence shows neutrophils are not the short-lived bystander they were once considered to be, but instead a persistent active player in cancer pathophysiology. By studying neutrophils from pleural fluid …

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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Pranvera Sadiku, Joseph A. Willson, Eilíse M. Ryan, David Sammut et autres

Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U- 13 C glucose, glutamine, and pyruvate, we observe that neutrophils require the generation of intracellular glycogen …

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Neutrophils in advanced non-small cell lung cancer

Robert Grecian

Lung cancer is the third most common cancer in the UK; 87% are histologically nonsmall cell lung cancer (NSCLC). At the time of diagnosis, patients frequently have advanced disease, with poor one-year survival due to metastatic burden. The immune system should act …

Proteomics identifies a type I IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS

Leila Reyes, Manuel A. Sánchez-García, Tyler E. Morrison, Andrew J.M. Howden et autres

Summary Understanding the mechanisms by which infection with SARS-CoV-2 leads to acute respiratory distress syndrome (ARDS) is of significant clinical interest given the mortality associated with severe and critical coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in the lung …

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