Youngro Byun

Synergistic anticancer immunity in metastatic triple-negative breast cancer through an in situ amplifying Peptide-Drug Conjugate

Ha Rin Kim, Seong Jin Park, Young Seok Cho, Yoon Gun Ko et autres

kr, Éthiopie, us, pr (code pays fourni par la source)

The prion-like protein Doppel: A soluble biomarker steering ovarian cancer’s peritoneal to circulatory dissemination

Zulfikar Azam, Xiaojun Zhang, Riajul Wahab, Md. Mahedi Hasan et autres

Abstract Detecting ovarian cancer (OC) early using existing biomarkers, e.g., cancer antigen 125 (CA125), is challenging due to its ubiquitous expression in many tissues. Doppel, a prion-like protein, expresses in male reproductive organ but absent in female reproductive systems and healthy tissues, …

us, kr (code pays fourni par la source)

Abstract 2710: Developing a novel doppel-targeting antibody-drug conjugate (ADC) for solid cancer

Ha Kyeong Lee, Byoungmo Kim, Seho Kweon, Jeong Uk Choi et autres

Abstract The development of anticancer therapeutics has two main objectives: enhancing efficacy and lowering toxicity. Given these goals, an antibody-drug conjugate (ADC), which delivers highly cytotoxic payloads to tumor tissue specifically, is one of the most favorable treatments. ADC is a growing …

kr (code pays fourni par la source)

Abstract 5091: Potentiating immunogenicity of PD1 blockage with metronomic Oral CAPOX for local and liver metastasized colorectal cancer

Seong Jin Park, Seho Kweon, Moyo Knowledge Mudhibadhi, Ha Rin Kim et autres

Abstract Since the appearance of oxaliplatin, FOLFOX therapy is positioned as the standard of care for colorectal cancer (CRC). And after the advent of capecitabine, an oral prodrug of 5-FU, both FOLFOX and CAPOX remain the first-line treatment for local and advanced …

Éthiopie (code pays fourni par la source)

Abstract 584: Doppel, an exosome mediated biomarker specific to tumor endothelial cells

Byoungmo Kim, Ha Kyeong Lee, Youngro Byun, Seung Rim Hwang et autres

Abstract The difficulty of finding a biomarker that is both specific and ubiquitous in cancer presents a barrier to targeted drug delivery. Some tumor-associated antigens are also found in normal tissue and contribute to “on-target toxicities”. Tumors are also heterogenous and plastic …

kr (code pays fourni par la source)

Abstract 2008: Induced macropinocytosis by DNA-PK inhibitor for KRAS mutant cancer targeting of albumin-binding peptide drug conjugate

Ha Rin Kim, Seong Jin Park, Moyo Knowledge Mudhibadhi, Jae Hee Park et autres

Abstract Although Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most well-known tumor driver gene with the highest mutation rate in several types of cancer, there is no effective mutant KRAS targeting drug yet. Recent studies have reported that macropinocytosis can …

Éthiopie (code pays fourni par la source)

Abstract 2730: Metronomic dose-finding approach of oral chemotherapy by experimentally-driven integrated mathematical modeling

Seho Kweon, Yoo‐Seong Jeong, Yoon Gun Ko, Seung Woo Chung et autres

Abstract Conventional chemotherapy with maximum tolerated dose (MTD) has shown confident anti-cancer effect and when combined with targeted therapy, immunotherapy. Yet, understanding about how the MTD regimen is optimized has lacked due to its high tumor burdens. In this study, the oral …

kr, us (code pays fourni par la source)

Abstract 339: Anti-doppel monoclonal antibody as a tumor endothelial cell-specific angiogenesis inhibitor

Ha Kyeong Lee, Ruby Maharjan, Yeojin Jeon, Jeong Uk Choi et autres

Abstract Introduction: Approved angiogenesis inhibitors generally target certain growth factors or their receptors, which exist in both normal and cancerous cells; this results in suppression of cell-signaling pathways throughout the body and causes adverse effects. For this reason, there is a need …

kr (code pays fourni par la source)

Near-to-far-field spectral evolution in a plasmonic crystal: Experimental verification of the equipartition of diffraction orders

Do Joon Park, K. G. Lee, H. W. Kihm, Youngro Byun et autres

We report on drastic changes in the near-field spectrum as it evolves into the far field in periodically corrugated metallic nanoslit arrays. The far-field spectral minimum is located exactly at the near-field spectral maximum, where a quasimonochromatic standing wave pattern is observed …

kr, de (code pays fourni par la source)