Stefan Arens

Modeling battery aging in linear energy system optimizations by applying convex hulls - accuracy benefits and computational costs

Geert Kristian Petrin, Stefan Arens, Patrik Schoenfeld, Peter Klement et autres

Linear energy system optimization plays an important role in the design of future energy systems, due to its availability and low computational requirements. While linear optimization offers many benefits, the rise in popularity of battery storage and its use cases represents a …

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Recovery from Pediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2: Follow-Up from a Nationwide German Cohort

Florens Lohrmann, Markus Hufnagel, Maren Doenhardt, Natalie Diffloth et autres

OBJECTIVE: To investigate the intermediate-term health impacts of pediatric inflammatory multisystem syndrome temporally-associated with SARS-CoV-2 (PIMS-TS). STUDY DESIGN: Using a standardized questionnaire in a multicenter study, follow-up data from acute PIMS-TS patients were collected, including detailed information on patient characteristics, clinical progression, …

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Clinical scores fail to sufficiently identify children with familial hypercholesterolaemia

Raphael Schmieder, Johannes Krefting, Sara Ates, Lea D. Schlieben et autres

AIMS: The study aimed to assess the effectiveness of three clinical diagnostic criteria [Simon Broome (SB), MEDPED (MP), and guideline-derived (GL-EAS)] in identifying children with familial hypercholesterolaemia (FH) compared with genetic testing. The evaluation involved 1337 children with elevated LDL cholesterol (LDL-C) …

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Distinct seasonality and increased respiratory failure in RSV patients < 2 years of age after emergence of SARS-CoV-2: data from the multicentric, prospective PAPI study

Jessica Bähre, Matthias Lange, Patrick Salaschek, Stefan Arens et autres

Respiratory syncytial virus (RSV) is a leading cause for global infant morbidity and mortality. The COVID-19 pandemic caused significant shifts in seasonality of RSV, and changes in disease severity have been matter of intense discussion. Between September 2020 and February 2023, the …

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Persistently high burden of acute respiratory infections requiring hospitalization in German pediatric hospitals, fall/winter 2023–2024

Svenja Dreßen, Josephine Schneider, Maren Doenhardt, Natalie Diffloth et autres

PURPOSE: During fall 2021, children's hospitals in Germany faced a surge in RSV-related hospitalizations, whereas during fall/winter 2022-2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively assessed severe acute respiratory infections, their causative pathogens, and the resulting …

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RSV is the main cause of severe respiratory infections in infants and young children in Germany - data from the prospective, multicenter PAPI study 2021–2023

Martin Wetzke, Matthias Lange, Cordula Koerner‐Rettberg, Alexander Kiefer et autres

BACKGROUND: Respiratory syncytial virus (RSV) is one of the main causes of morbidity in infants and young children worldwide. Current data on RSV-associated disease burden in Germany before the introduction of new immunization strategies is lacking. METHODS: The PAPI study is a …

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Pareto Optimization of the Integration of Renewables for the Supply of Battery‐Electric and Hydrogen‐Electric Multiple Units at a Single Site

Stefan Arens, Alexander Windt, Christoph Streuling, Benedikt Hanke

ABSTRACT Battery‐ and hydrogen‐powered trains are emerging technologies that have the potential to play a key role in the decarbonization of railway lines for which full trackside electrification is not feasible. In this study, we examine Pareto‐optimal energy supply concepts for a …

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Severity of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Diminished During Successive Waves of the COVID-19 Pandemic: Data from a Nationwide German Survey

Florens Lohrmann, Maren Doenhardt, Natalie Diffloth, André Jakob et autres

OBJECTIVE: To elucidate how the clinical presentation of Pediatric Inflammatory Multisystem Syndrome temporally associated with Severe Acute Respiratory Syndrome-related Coronavirus 2 (PIMS-TS) was influenced by the successive variants of concern (VOC) and patient age. STUDY DESIGN: A nationwide PIMS-TS registry was established …

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Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt, Markus Hufnagel, Natalie Diffloth, Johannes Hübner et autres

By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020-November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated …

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High burden of acute respiratory tract infections leading to hospitalization at German pediatric hospitals: fall/winter 2022–2023

Maren Doenhardt, Jakob Armann, Natalie Diffloth, Christin Gano et autres

PURPOSE: Given reduced immunity levels for seasonally occurring respiratory infections and the experience of an unusually early, severe wave of RSV infections during 2021, a preexisting clinician-led reporting system (CLRS) was updated to prospectively monitor the anticipated high burden of respiratory infections …

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A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel, Jakob Armann, André Jakob, Maren Doenhardt et autres

The connection between Pediatric Inflammatory Multisystem Syndrome (PIMS) and Kawasaki Disease (KD) is not yet fully understood. Using the same national registry, clinical features and outcome of children hospitalized in Germany, and Innsbruck (Austria) were compared. Reported to the registry were 395 …

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Universal Screening for Familial Hypercholesterolemia in Two Populations

Urša Šuštar, Matej Mlinarič, Jernej Kovač, Stefan Arens et autres