Jennifer R. Klemp

Influence of genetic ancestry on UV mutational signatures linked to immunotherapy response in melanoma, beyond TMB.

Kevin Magnaye, Brady Gilg, Lauren R. Dickman, Rosemary N. Plagens et autres

3087 Background: Melanoma is a UV-driven malignancy with substantial biological heterogeneity, yet genomic profiling efforts have historically underrepresented diverse ancestral backgrounds, limiting insights into population-level differences in tumor biology and treatment response. Methods: In this retrospective study, a supervised machine learning framework …

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Transition to Survivorship

Pamela Goetz, Jennifer R. Klemp, Linda Burhansstipanov, Jason King

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Pathological Response and Survival in Triple-Negative Breast Cancer Following Neoadjuvant Carboplatin plus Docetaxel

José Á. García-Sáenz, Sara López‐Tarruella, Hugo Alejandro Fuentes, Qamar J. Khan et autres

PURPOSE: Prognostic value of pathologic complete response (pCR) and extent of pathologic response attained with anthracycline-free platinum plus taxane neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) is unknown. We report recurrence-free survival (RFS) and overall survival (OS) according to degree of …

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Protocol for the rural engagement in TelemedTeam for options in obesity treatment solutions (RE-TOOL): Cluster randomized trial investigating team-based telemedicine in rural primary care

Alexandra R. Brown, Edward F. Ellerbeck, Debra K. Sullivan, Eve‐Lynn Nelson et autres

Rural communities experience disproportionately high rates of obesity and related chronic diseases. Rural residents report a lack of weight control programs within their communities, leaving primary care physicians (PCPs)at the center of obesity treatment. PCP involvement significantly enhances uptake and maintenance of …

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Abstract P1-03-15: Characterization of metabolic and energetic risk factors and preventative breast surgical decisions in a cross-sectional survey cohort of hereditary cancer pathogenic variant carriers

Lauren Elizabeth Nye, Catherine J. Knight, Jennifer R. Klemp, Lyndsey J. Kilgore

Abstract Background: About 10% of all breast cancers (BC) result from an inherited pathogenic variant (PV). Energetics and Lifestyle in Inherited Syndromes (ELLIES) Project is a survey-based study examining diet, exercise and metabolic risk factors in individuals with hereditary cancer pathogenic variants …

Understanding facilitators and barriers to genetic testing for black ovarian cancer patients: A qualitative study utilizing interview data with patients and providers

Chelsea Salyer, Erika Gazetta, Cassandra Voth, Lori Ann Spoozak et autres

Studies consistently demonstrate that Black ovarian cancer patients are less likely to receive guideline-recommended genetic testing. The current study explored barriers to genetic testing among Black women from the perspective of key stakeholders. We conducted semi-structured interviews with patients (n = 5), …

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Enhancing capacity for primary care research in cancer survivorship: National Cancer Institute meeting report

Shawna V. Hudson, Michelle A. Mollica, Crystal Reed, Erin Elizabeth Hahn et autres

Many components of long-term cancer follow-up and survivorship care are managed in the primary care context. Given the important role that primary care has in survivorship care, it is critical to ensure that teams in these settings are prepared to address long-term …

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Validation of a clinical breast cancer risk assessment tool combining a polygenic score for all ancestries with traditional risk factors

Brent Mabey, Elisha Hughes, Matthew T. Kucera, Timothy C. Simmons et autres

PURPOSE: We previously described a combined risk score (CRS) that integrates a multiple-ancestry polygenic risk score (MA-PRS) with the Tyrer-Cuzick (TC) model to assess breast cancer (BC) risk. Here, we present a longitudinal validation of CRS in a real-world cohort. METHODS: This …

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KANSURVIVE: Testing a telementoring model for improving cancer survivorship care in rural practice.

Jennifer R. Klemp, Catherine J. Knight, Edward F. Ellerbeck, Christie A. Befort et autres

e13791 Background: Cancer survivors require long-term, coordinated care to address the physical, emotional, and psychosocial effects of cancer and its treatment. KanSurvive, a single arm feasibility trial, evaluated the effectiveness of the KanSurvive ECHO intervention combined with practice facilitation (PF) to promote …

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Barriers to uptake of genetic services among ovarian cancer patients at a university-based national cancer institute designated cancer center: Who are we missing? (2160)

Cassandra Voth, Erika Gazzetta, Sharon Fitzgerald, Megha Ramaswamy et autres

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Experiences of genetic counselors in referring young and metastatic breast cancer patients to support services: A needs assessment

Elizabeth Bourquardez Clark, Katherine E. Bonini, Robin Hilary Pugh Yi, Erica Kuhn et autres

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Polygenic risk score calibration and association with breast cancer in diverse ancestries.

Matthew T. Kucera, Elisha Hughes, Brent Mabey, Brooke Hullinger et autres

10505 Background: Polygenic risk scores (PRS) have been shown to substantially improve breast cancer (BC) risk prediction when incorporated into traditional risk assessment models. However, PRS developed primarily in women of European ancestry have shown poor performance when applied to non-European populations. …

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