Wei Yuan

A Phase I trial of the anti-IL23 monoclonal antibody tildrakizumab, in combination with abiraterone acetate, for the treatment of metastatic castration-resistant prostate cancer

Khobe Chandran, Christina Guo, Simon Pacey, Guillermo Villacampa et autres

Biotic-response networks are an important organizer of the transcriptome in wild Arabidopsis thaliana populations

Ana Paula Leite Montalvão, Kevin Murray, Ilja Bezrukov, Natalie Betz et autres

Abstract Extensive laboratory experimentation has revealed conserved molecular pathways controlling growth and stress responses in plants, yet how these programs operate in natural settings remains poorly understood. We investigated transcriptome organization in wild populations of Arabidopsis thaliana by sampling plants from 60 …

de, us, fr, kr, Éthiopie (code pays fourni par la source)

The Ecological Genomic Processes of the Iconic Japanese Knotweed Invasion

Bethany Burns, Malika L. Aïnouche, Elena Barni, Jingwen Bi et autres

Many plant invasions establish from only a few individuals and exhibit clonal spread, providing an opportunity to examine the genomic mechanisms that underlie the success of particularly aggressive individuals. One of the world’s most invasive species, the Japanese knotweed complex, is well …

us, fr, it, cn, de, se, fi (code pays fourni par la source)

Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis

Li He, Yao Yao, Xiaofei Wei, Wei Yuan et autres

Tools to edit DNA methylation in a targeted manner are vital for establishing causal relationships between DNA methylation and its function, as well as for plant breeding and gene therapy. Here, by constructing dCas9 fusions to a panel of effectors and cofactors, …

cn, de (code pays fourni par la source)

Assessing the Genetic Integrity of Embryos Carrying X/Y-Autosome-Balanced Translocations through SNP-Based PGT-SR

Yueyun Lan, Jinhui Shu, Sheng He, Jingsi Luo et autres

INTRODUCTION: The influence of X/Y-autosomal translocations on reproductive competence is determined by both the cytogenetic positioning of translocation breakpoints and the potential disruption of critical genomic regions essential for reproductive physiology, particularly gene-dense Y-chromosomal segments or X-chromosome loci associated with ovarian folliculogenesis. …

cn (code pays fourni par la source)

Prediction of twin preterm birth based on quadratic discriminant analysis and electrohysterogram

Ting Sun, Shuang Li, Wei Yuan, Haijun Niu

Preterm birth is a significant cause of adverse maternal and fetal outcomes. Clinical evidence demonstrates a significantly higher incidence of preterm birth in twin pregnancies compared to singletons. This study evaluates the feasibility of using electrohysterogram in combination with quadratic discriminant analysis …

cn (code pays fourni par la source)

A major trade-off between growth and defense in Arabidopsis thaliana can vanish in field conditions

Derek S. Lundberg, Sonja Kersten, E. Boz, Pratchaya Pramoj Na Ayutthaya et autres

When wild plants defend themselves from pathogens, this often comes with a trade-off: the same genes that protect a plant from disease can also reduce its growth and fecundity in the absence of pathogens. One protein implicated in a major growth-defense trade-off …

se, de, cn (code pays fourni par la source)

Species-wide gene editing of a flowering regulator reveals hidden phenotypic variation

Ulrich Lutz, Ilja Bezrukov, Rebecca Schwab, Wei Yuan et autres

Genes do not act in isolation, and the effects of a specific variant at one locus can often be greatly modified by polymorphic variants at other loci. A good example is FLOWERING LOCUS C (FLC), which has been inferred to explain much …

de (code pays fourni par la source)

Changes in Fibrinogen and D‐Dimer During Complicated and Uncomplicated Pregnancy

Hai Jiang, Yang Su, Jing Yang, Wei Yuan et autres

INTRODUCTION: The increase in fibrinogen levels is vital for the formation of a prothrombotic state during gestation to counter-bleeding challenges at delivery. However, pregnancy complications characterized by systemic inflammatory response syndrome may consume fibrinogen, resulting in elevated D-dimer levels. METHODS: Our study …

cn (code pays fourni par la source)

Transcriptomic analysis identified novel biomarker in invasive placenta accreta spectrum

Xiaoming Shi, Ling Jin, Xinlu Meng, Xiao Huo et autres

cn (code pays fourni par la source)

Field conditions greatly modify a major growth-defense tradeoff in Arabidopsis thaliana

Derek S. Lundberg, Sonja Kersten, Ezgi Mehmetoğlu, Pratchaya Pramoj Na Ayutthaya et autres

Abstract When plants defend themselves from pathogens, this often comes with a trade-off: the same genes that protect a plant from disease can also reduce its growth and fecundity in the absence of pathogens. One protein implicated in a major growth-defense trade-off …

se, de, cn (code pays fourni par la source)

Rapid phenotypic differentiation in the iconic Japanese knotweed s.l. invading novel habitats

Wei Yuan, Massimo Pigliucci, Christina L. Richards

Understanding the mechanisms that underlie plant invasions is critical for management and conservation of biodiversity. At the same time, invasive species also provide a unique opportunity to study rapid adaptation to complex environmental conditions. Using four replicate reciprocal transplant experiments across three …

de, us (code pays fourni par la source)